Targeting a Lipid Desaturation Enzyme, SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling

Targeting a Lipid Desaturation Enzyme, SCD1, Selectively Eliminates Colon Cancer Stem Cells through the Suppression of Wnt and NOTCH Signaling

The elimination of the cancer stem cell (CSC) population may be required to achieve better outcomes of cancer therapy. We evaluated stearoyl-CoA desaturase 1 (SCD1) as a novel target for CSC-selective elimination in colon cancer. CSCs expressed more SCD1 than bulk cultured cells (BCCs), and blocking...

Full description

Bibliographic Details
Main Authors: Yeongji Yu, Hyejin Kim, SeokGyeong Choi, JinSuh Yu, Joo Yeon Lee, Hani Lee, Sukjoon Yoon, Woo-Young Kim
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
CSC
SCD1
monounsaturated fatty acid
NOTCH
Wnt
Online Access:https://www.mdpi.com/2073-4409/10/1/106

Similar Items

Similar Items