FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

Summary: Idiopathic pulmonary fibrosis is a common form of interstitial lung disease resulting in alveolar remodeling and progressive loss of pulmonary function because of chronic alveolar injury and failure to regenerate the respiratory epithelium. Histologically, fibrotic lesions and honeycomb str...

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Main Authors: Tingting Yuan, Thomas Volckaert, Elizabeth F. Redente, Seantel Hopkins, Kylie Klinkhammer, Roxana Wasnick, Cho-Ming Chao, Jie Yuan, Jin-San Zhang, Changfu Yao, Susan Majka, Barry R. Stripp, Andreas Günther, David W.H. Riches, Saverio Bellusci, Victor J. Thannickal, Stijn P. De Langhe
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119301250

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