NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19
Objective: To determine and compare Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in predicting severity of disease in patients with COVID-19. Study design: Descriptive comparative study. Place and Duration of study: Department of Medicine, CMH Thal from April to...
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doaj-fcc7efe337174fab8d36de392824c7a42021-09-09T19:31:09ZengThe Army PressPakistan Armed Forces Medical Journal0030-96482411-88422020-12-0170616091615https://doi.org/10.51253/pafmj.v70i6.50105010NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19Muhammad Adil0Zahid Farooq Baig1Muhammad Amir2Sohail Saqib Chatha3Aamir Habib4Muhammad Majid5Graded Medical Specialist, Combined Military Hospital, Thal PakistanCombined Military Hospital Lahore/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital Peshawar/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital Thal/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital Bannu/National University of Medical Sciences (NUMS) PakistaCombined Military Hospital Kohat/National University of Medical Sciences (NUMS) PakistaObjective: To determine and compare Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in predicting severity of disease in patients with COVID-19. Study design: Descriptive comparative study. Place and Duration of study: Department of Medicine, CMH Thal from April to July, 2020 Patients & Methods: 61 patients of COVID-19 confirmed through polymerase chain reaction were recruited and divided into severe and non severe disease. Complete blood counts were done. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio were calculated and analyzed. Results: 14 patients (23%) of severe disease had mean age of 49.93±19.42 and 47 patients (77%) with non-severe disease had mean age of 33.32±9.16. The mean Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte ratio in patients who had severe disease was 7.20±4.20 and 204.25±148.42 (p=0.001 and p=0.026) respectively. The diagnostic performance of both Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio produced statistically significant area under the curve (AUC), (p <0.001). The adjusted and unadjusted area under curve for Neutrophil to Lymphocyte Ratio was 0.92 (95% CI: 0.85–1.00) and 0.923 (95% CI: 0.839-1.000) and for Platelet to Lymphocyte Ratio it was 0.883 (95% CI: 0.781–0.985) and 0.825(95% CI: 0.707-0.943) respectively. Conclusion: Elevated Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are independent biomarkers which predict severity of disease in COVID-19 patients with Neutrophil to Lymphocyte Ratio being better predictor in terms of diagnostic accuracy. https://pafmj.org/index.php/PAFMJ/article/view/5010corona virus disease 2019 (covid‐19)neutrophil to lymphocyte ratioplatelet to lymphocyte ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Muhammad Adil Zahid Farooq Baig Muhammad Amir Sohail Saqib Chatha Aamir Habib Muhammad Majid |
spellingShingle |
Muhammad Adil Zahid Farooq Baig Muhammad Amir Sohail Saqib Chatha Aamir Habib Muhammad Majid NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 Pakistan Armed Forces Medical Journal corona virus disease 2019 (covid‐19) neutrophil to lymphocyte ratio platelet to lymphocyte ratio |
author_facet |
Muhammad Adil Zahid Farooq Baig Muhammad Amir Sohail Saqib Chatha Aamir Habib Muhammad Majid |
author_sort |
Muhammad Adil |
title |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
title_short |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
title_full |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
title_fullStr |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
title_full_unstemmed |
NEUTROPHIL TO LYMPHOCYTE RATIO VS PLATELETS TO LYMPHOCYTE RATIO: BIOMARKERS TO PREDICT SEVERITY OF DISEASE AND THEIR COMPARISON IN PATIENTS OF COVID-19 |
title_sort |
neutrophil to lymphocyte ratio vs platelets to lymphocyte ratio: biomarkers to predict severity of disease and their comparison in patients of covid-19 |
publisher |
The Army Press |
series |
Pakistan Armed Forces Medical Journal |
issn |
0030-9648 2411-8842 |
publishDate |
2020-12-01 |
description |
Objective: To determine and compare Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in predicting severity of disease in patients with COVID-19.
Study design: Descriptive comparative study.
Place and Duration of study: Department of Medicine, CMH Thal from April to July, 2020
Patients & Methods: 61 patients of COVID-19 confirmed through polymerase chain reaction were recruited and divided into severe and non severe disease. Complete blood counts were done. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio were calculated and analyzed.
Results: 14 patients (23%) of severe disease had mean age of 49.93±19.42 and 47 patients (77%) with non-severe disease had mean age of 33.32±9.16. The mean Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte ratio in patients who had severe disease was 7.20±4.20 and 204.25±148.42 (p=0.001 and p=0.026) respectively. The diagnostic performance of both Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio produced statistically significant area under the curve (AUC), (p <0.001). The adjusted and unadjusted area under curve for Neutrophil to Lymphocyte Ratio was 0.92 (95% CI: 0.85–1.00) and 0.923 (95% CI: 0.839-1.000) and for Platelet to Lymphocyte Ratio it was 0.883 (95% CI: 0.781–0.985) and 0.825(95% CI: 0.707-0.943) respectively.
Conclusion: Elevated Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are independent biomarkers which predict severity of disease in COVID-19 patients with Neutrophil to Lymphocyte Ratio being better predictor in terms of diagnostic accuracy. |
topic |
corona virus disease 2019 (covid‐19) neutrophil to lymphocyte ratio platelet to lymphocyte ratio |
url |
https://pafmj.org/index.php/PAFMJ/article/view/5010 |
work_keys_str_mv |
AT muhammadadil neutrophiltolymphocyteratiovsplateletstolymphocyteratiobiomarkerstopredictseverityofdiseaseandtheircomparisoninpatientsofcovid19 AT zahidfarooqbaig neutrophiltolymphocyteratiovsplateletstolymphocyteratiobiomarkerstopredictseverityofdiseaseandtheircomparisoninpatientsofcovid19 AT muhammadamir neutrophiltolymphocyteratiovsplateletstolymphocyteratiobiomarkerstopredictseverityofdiseaseandtheircomparisoninpatientsofcovid19 AT sohailsaqibchatha neutrophiltolymphocyteratiovsplateletstolymphocyteratiobiomarkerstopredictseverityofdiseaseandtheircomparisoninpatientsofcovid19 AT aamirhabib neutrophiltolymphocyteratiovsplateletstolymphocyteratiobiomarkerstopredictseverityofdiseaseandtheircomparisoninpatientsofcovid19 AT muhammadmajid neutrophiltolymphocyteratiovsplateletstolymphocyteratiobiomarkerstopredictseverityofdiseaseandtheircomparisoninpatientsofcovid19 |
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