Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, includ...

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Main Authors: Sonali Nashine, M. Cristina Kenney
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
MDPs
mitochondrial-derived peptides
Humanin
HNG
SHLPs
MOTS-c
Online Access:https://www.mdpi.com/2073-4409/9/5/1102
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spelling doaj-fcc8b07b306e48d4b33c5980cba4c3da2020-11-25T02:36:29ZengMDPI AGCells2073-44092020-04-0191102110210.3390/cells9051102Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMDSonali Nashine0M. Cristina Kenney1Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USADepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USASubstantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.https://www.mdpi.com/2073-4409/9/5/1102MDPsmitochondrial-derived peptidesHumaninHNGSHLPsMOTS-c
collection DOAJ
language English
format Article
sources DOAJ
author Sonali Nashine
M. Cristina Kenney
spellingShingle Sonali Nashine
M. Cristina Kenney
Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
Cells
MDPs
mitochondrial-derived peptides
Humanin
HNG
SHLPs
MOTS-c
author_facet Sonali Nashine
M. Cristina Kenney
author_sort Sonali Nashine
title Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_short Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_full Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_fullStr Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_full_unstemmed Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD
title_sort effects of mitochondrial-derived peptides (mdps) on mitochondrial and cellular health in amd
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-04-01
description Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.
topic MDPs
mitochondrial-derived peptides
Humanin
HNG
SHLPs
MOTS-c
url https://www.mdpi.com/2073-4409/9/5/1102
work_keys_str_mv AT sonalinashine effectsofmitochondrialderivedpeptidesmdpsonmitochondrialandcellularhealthinamd
AT mcristinakenney effectsofmitochondrialderivedpeptidesmdpsonmitochondrialandcellularhealthinamd
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