The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma

The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma is one of the deadliest tumors. This neoplasia is characterized by an important cellular and phenotypic heterogeneity. In particular, it has been shown that at least two subtypes can be found: basal-like, which presents stem-like properties, and classical. Cancer ste...

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Main Authors: Jorge Melendez-Zajgla, Vilma Maldonado
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
tumor initiating cells
cancer stem cells
non-coding RNAs
Online Access:https://www.mdpi.com/1422-0067/22/12/6374
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spelling doaj-fcd0c4d4ea024e47b5035cf57b1b5d772021-07-01T00:10:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226374637410.3390/ijms22126374The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal AdenocarcinomaJorge Melendez-Zajgla0Vilma Maldonado1Functional Genomics Laboratory, Instituto Nacional de Medicina Genomica, Periferico Sur 4809, Tlalpan, Mexico City 14610, MexicoEpigenomics Laboratory, Instituto Nacional de Medicina Genomica, Periferico Sur 4809, Tlalpan, Mexico City 14610, MexicoPancreatic ductal adenocarcinoma is one of the deadliest tumors. This neoplasia is characterized by an important cellular and phenotypic heterogeneity. In particular, it has been shown that at least two subtypes can be found: basal-like, which presents stem-like properties, and classical. Cancer stem cells have been isolated and characterized from these tumors, showing their dependance on general and tissue-specific stem transcription factors and signaling pathways. Nevertheless, little is known about their tissue microenvironment and cell non-autonomous regulators, such as long-non-coding RNAs. (lncRNAs). In this review, we summarize the current knowledge about the positive and negative effects of lncRNAs in the stemness phenotype of pancreatic ductal adenocarcinoma cancer (PDAC).https://www.mdpi.com/1422-0067/22/12/6374tumor initiating cellscancer stem cellsnon-coding RNAs
collection DOAJ
language English
format Article
sources DOAJ
author Jorge Melendez-Zajgla
Vilma Maldonado
spellingShingle Jorge Melendez-Zajgla
Vilma Maldonado
The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma
International Journal of Molecular Sciences
tumor initiating cells
cancer stem cells
non-coding RNAs
author_facet Jorge Melendez-Zajgla
Vilma Maldonado
author_sort Jorge Melendez-Zajgla
title The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma
title_short The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma
title_full The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma
title_fullStr The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma
title_full_unstemmed The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma
title_sort role of lncrnas in the stem phenotype of pancreatic ductal adenocarcinoma
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-06-01
description Pancreatic ductal adenocarcinoma is one of the deadliest tumors. This neoplasia is characterized by an important cellular and phenotypic heterogeneity. In particular, it has been shown that at least two subtypes can be found: basal-like, which presents stem-like properties, and classical. Cancer stem cells have been isolated and characterized from these tumors, showing their dependance on general and tissue-specific stem transcription factors and signaling pathways. Nevertheless, little is known about their tissue microenvironment and cell non-autonomous regulators, such as long-non-coding RNAs. (lncRNAs). In this review, we summarize the current knowledge about the positive and negative effects of lncRNAs in the stemness phenotype of pancreatic ductal adenocarcinoma cancer (PDAC).
topic tumor initiating cells
cancer stem cells
non-coding RNAs
url https://www.mdpi.com/1422-0067/22/12/6374
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