Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma
Background: Positron emission tomography with <sup>11</sup>C-methionine (MET) is well established in the diagnostic work-up of malignant brain tumors. Texture analysis is a novel technique for extracting information regarding relationships among surrounding voxels, in order to quantify t...
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doaj-fcd6632f4909472285d959d927338d042021-01-29T00:07:46ZengMDPI AGDiagnostics2075-44182021-01-011118918910.3390/diagnostics11020189Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for GliomaOsamu Manabe0Shigeru Yamaguchi1Kenji Hirata2Kentaro Kobayashi3Hiroyuki Kobayashi4Shunsuke Terasaka5Takuya Toyonaga6Keiichi Magota7Yuji Kuge8Nagara Tamaki9Tohru Shiga10Kohsuke Kudo11Department of Radiology, Saitama Medical Center Jichi Medical University, 1-847, Amanuma-cho, Saitama-shi, Saitama-ken 330-8503, JapanDepartment of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, JapanDepartment of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, JapanDepartment of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, JapanDepartment of Neurosurgery, Kashiwaba Neurosurgery Hospital, Sapporo 062-8513, JapanDepartment of Neurosurgery, Kashiwaba Neurosurgery Hospital, Sapporo 062-8513, JapanPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USADivision of Medical Imaging and Technology, Hokkaido University Hospital, Sapporo 060-8648, JapanCentral Institute of Isotope Science, Hokkaido University, Sapporo 060-8638, JapanDepartment of Radiology, Kyoto Prefectural University, Kyoto 606-8522, JapanDepartment of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, JapanDepartment of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, JapanBackground: Positron emission tomography with <sup>11</sup>C-methionine (MET) is well established in the diagnostic work-up of malignant brain tumors. Texture analysis is a novel technique for extracting information regarding relationships among surrounding voxels, in order to quantify their inhomogeneity. This study evaluated whether the texture analysis of MET uptake has prognostic value for patients with glioma. Methods: We retrospectively analyzed adults with glioma who had undergone preoperative metabolic imaging at a single center. Tumors were delineated using a threshold of 1.3-fold of the mean standardized uptake value for the contralateral cortex, and then processed to calculate the texture features in glioma. Results: The study included 42 patients (median age: 56 years). The World Health Organization classifications were grade II (7 patients), grade III (17 patients), and grade IV (18 patients). Sixteen (16.1%) all-cause deaths were recorded during the median follow-up of 18.8 months. The univariate analyses revealed that overall survival (OS) was associated with age (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.01–1.08, <em>p </em>= 0.0093), tumor grade (HR 3.64, 95% CI 1.63–9.63, <em>p </em>= 0.0010), genetic status (<em>p </em>< 0.0001), low gray-level run emphasis (LGRE, calculated from the gray-level run-length matrix) (HR 2.30 × 10<sup>11</sup>, 95% CI 737.11–4.23 × 10<sup>19</sup>, <em>p </em>= 0.0096), and correlation (calculated from the gray-level co-occurrence matrix) (HR 5.17, 95% CI 1.07–20.93, <em>p </em>= 0.041). The multivariate analyses revealed OS was independently associated with LGRE and correlation. The survival curves were also significantly different (both log-rank <em>p </em>< 0.05). Conclusion: Textural features obtained using preoperative MET positron emission tomography may compliment the semi-quantitative assessment for prognostication in glioma cases.https://www.mdpi.com/2075-4418/11/2/189methioninepositron emission tomographygliomatexture analysisprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Osamu Manabe Shigeru Yamaguchi Kenji Hirata Kentaro Kobayashi Hiroyuki Kobayashi Shunsuke Terasaka Takuya Toyonaga Keiichi Magota Yuji Kuge Nagara Tamaki Tohru Shiga Kohsuke Kudo |
spellingShingle |
Osamu Manabe Shigeru Yamaguchi Kenji Hirata Kentaro Kobayashi Hiroyuki Kobayashi Shunsuke Terasaka Takuya Toyonaga Keiichi Magota Yuji Kuge Nagara Tamaki Tohru Shiga Kohsuke Kudo Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma Diagnostics methionine positron emission tomography glioma texture analysis prognosis |
author_facet |
Osamu Manabe Shigeru Yamaguchi Kenji Hirata Kentaro Kobayashi Hiroyuki Kobayashi Shunsuke Terasaka Takuya Toyonaga Keiichi Magota Yuji Kuge Nagara Tamaki Tohru Shiga Kohsuke Kudo |
author_sort |
Osamu Manabe |
title |
Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma |
title_short |
Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma |
title_full |
Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma |
title_fullStr |
Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma |
title_full_unstemmed |
Preoperative Texture Analysis Using <sup>11</sup>C-Methionine Positron Emission Tomography Predicts Survival after Surgery for Glioma |
title_sort |
preoperative texture analysis using <sup>11</sup>c-methionine positron emission tomography predicts survival after surgery for glioma |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-01-01 |
description |
Background: Positron emission tomography with <sup>11</sup>C-methionine (MET) is well established in the diagnostic work-up of malignant brain tumors. Texture analysis is a novel technique for extracting information regarding relationships among surrounding voxels, in order to quantify their inhomogeneity. This study evaluated whether the texture analysis of MET uptake has prognostic value for patients with glioma. Methods: We retrospectively analyzed adults with glioma who had undergone preoperative metabolic imaging at a single center. Tumors were delineated using a threshold of 1.3-fold of the mean standardized uptake value for the contralateral cortex, and then processed to calculate the texture features in glioma. Results: The study included 42 patients (median age: 56 years). The World Health Organization classifications were grade II (7 patients), grade III (17 patients), and grade IV (18 patients). Sixteen (16.1%) all-cause deaths were recorded during the median follow-up of 18.8 months. The univariate analyses revealed that overall survival (OS) was associated with age (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.01–1.08, <em>p </em>= 0.0093), tumor grade (HR 3.64, 95% CI 1.63–9.63, <em>p </em>= 0.0010), genetic status (<em>p </em>< 0.0001), low gray-level run emphasis (LGRE, calculated from the gray-level run-length matrix) (HR 2.30 × 10<sup>11</sup>, 95% CI 737.11–4.23 × 10<sup>19</sup>, <em>p </em>= 0.0096), and correlation (calculated from the gray-level co-occurrence matrix) (HR 5.17, 95% CI 1.07–20.93, <em>p </em>= 0.041). The multivariate analyses revealed OS was independently associated with LGRE and correlation. The survival curves were also significantly different (both log-rank <em>p </em>< 0.05). Conclusion: Textural features obtained using preoperative MET positron emission tomography may compliment the semi-quantitative assessment for prognostication in glioma cases. |
topic |
methionine positron emission tomography glioma texture analysis prognosis |
url |
https://www.mdpi.com/2075-4418/11/2/189 |
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