White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia
Schizophrenia is a severe mental disorder affecting about 1% of the population worldwide. Although the dopamine (DA) hypothesis is still keeping a dominant position in schizophrenia research, new advances have been emerging in recent years, which suggest the implication of white matter abnormalities...
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2011-01-01
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Series: | Schizophrenia Research and Treatment |
Online Access: | http://dx.doi.org/10.1155/2011/826976 |
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doaj-fce2903da3bc42839880b660923b992f2020-11-24T22:57:47ZengHindawi LimitedSchizophrenia Research and Treatment2090-20852090-20932011-01-01201110.1155/2011/826976826976White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in SchizophreniaHaiyun Xu0Xin-Min Li1Department of Anatomy, Southern Illinois University Carbondale, Carbondale, IL 62901, USADepartment of Psychiatry, Faculty of Medicine, University of Manitoba, Winnipeg, MB, R3T 2N2, CanadaSchizophrenia is a severe mental disorder affecting about 1% of the population worldwide. Although the dopamine (DA) hypothesis is still keeping a dominant position in schizophrenia research, new advances have been emerging in recent years, which suggest the implication of white matter abnormalities in schizophrenia. In this paper, we will briefly review some of recent human studies showing white matter abnormalities in schizophrenic brains and altered oligodendrocyte-(OL-) and myelin-related genes in patients with schizophrenia and will consider abnormal behaviors reported in patients with white matter diseases. Following these, we will selectively introduce some animal models examining a putative role of white matter abnormalities in schizophrenia. The emphasis will be put on the cuprizone (CPZ) model. CPZ-fed mice show demyelination and OLs loss, display schizophrenia-related behaviors, and have higher DA levels in the prefrontal cortex. These features suggest that the CPZ model is a novel animal model of schizophrenia.http://dx.doi.org/10.1155/2011/826976 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haiyun Xu Xin-Min Li |
spellingShingle |
Haiyun Xu Xin-Min Li White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia Schizophrenia Research and Treatment |
author_facet |
Haiyun Xu Xin-Min Li |
author_sort |
Haiyun Xu |
title |
White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia |
title_short |
White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia |
title_full |
White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia |
title_fullStr |
White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia |
title_full_unstemmed |
White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia |
title_sort |
white matter abnormalities and animal models examining a putative role of altered white matter in schizophrenia |
publisher |
Hindawi Limited |
series |
Schizophrenia Research and Treatment |
issn |
2090-2085 2090-2093 |
publishDate |
2011-01-01 |
description |
Schizophrenia is a severe mental disorder affecting about 1% of the population worldwide. Although the dopamine (DA) hypothesis is still keeping a dominant position in schizophrenia research, new advances have been emerging in recent years, which suggest the implication of white matter abnormalities in schizophrenia. In this paper, we will briefly review some of recent human studies showing white matter abnormalities in schizophrenic brains and altered oligodendrocyte-(OL-) and myelin-related genes in patients with schizophrenia and will consider abnormal behaviors reported in patients with white matter diseases. Following these, we will selectively introduce some animal models examining a putative role of white matter abnormalities in schizophrenia. The emphasis will be put on the cuprizone (CPZ) model. CPZ-fed mice show demyelination and OLs loss, display schizophrenia-related behaviors, and have higher DA levels in the prefrontal cortex. These features suggest that the CPZ model is a novel animal model of schizophrenia. |
url |
http://dx.doi.org/10.1155/2011/826976 |
work_keys_str_mv |
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1725649189200723968 |