Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function
In the core mammalian circadian negative feedback loop, the BMAL1-CLOCK complex activates the transcription of the genes Period (Per) and Cryptochrome (Cry). To close the negative feedback loop, the PER-CRY complex interacts with the BMAL1-CLOCK complex to repress its activity. These two processes a...
Main Authors: | Guangsen Shi, Pancheng Xie, Zhipeng Qu, Zhihui Zhang, Zhen Dong, Yang An, Lijuan Xing, Zhiwei Liu, Yingying Dong, Guoqiang Xu, Ling Yang, Yi Liu, Ying Xu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-02-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715015326 |
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