Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease

Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow’s disease. The aim of this review was to describe th...

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Main Authors:	Aniek L. van Wijngaarden, Boudewijn P. T. Kruithof, Tommaso Vinella, Daniela Q. C. M. Barge-Schaapveld, Nina Ajmone Marsan
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Journal of Cardiovascular Development and Disease
Subjects:	mitral valve prolapse imaging mitral valve surgery
Online Access:	https://www.mdpi.com/2308-3425/8/2/23

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spelling	doaj-fcf89944ccd34881bb00ed67223b583c2021-02-23T00:04:09ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-02-018232310.3390/jcdd8020023Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s DiseaseAniek L. van Wijngaarden0Boudewijn P. T. Kruithof1Tommaso Vinella2Daniela Q. C. M. Barge-Schaapveld3Nina Ajmone Marsan4Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsFaculty of Medicine, University of Southampton, Southampton SO17 1BJ, UKDepartment of Clinical Genetics, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDegenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow’s disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow’s disease, highlighting the differences in diagnosis, risk stratification and patient management, but also the still significant gaps in understanding the exact pathophysiology of these two phenotypes.https://www.mdpi.com/2308-3425/8/2/23mitral valve prolapseimagingmitral valve surgery
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Aniek L. van Wijngaarden Boudewijn P. T. Kruithof Tommaso Vinella Daniela Q. C. M. Barge-Schaapveld Nina Ajmone Marsan
spellingShingle	Aniek L. van Wijngaarden Boudewijn P. T. Kruithof Tommaso Vinella Daniela Q. C. M. Barge-Schaapveld Nina Ajmone Marsan Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease Journal of Cardiovascular Development and Disease mitral valve prolapse imaging mitral valve surgery
author_facet	Aniek L. van Wijngaarden Boudewijn P. T. Kruithof Tommaso Vinella Daniela Q. C. M. Barge-Schaapveld Nina Ajmone Marsan
author_sort	Aniek L. van Wijngaarden
title	Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease
title_short	Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease
title_full	Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease
title_fullStr	Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease
title_full_unstemmed	Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease
title_sort	characterization of degenerative mitral valve disease: differences between fibroelastic deficiency and barlow’s disease
publisher	MDPI AG
series	Journal of Cardiovascular Development and Disease
issn	2308-3425
publishDate	2021-02-01
description	Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow’s disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow’s disease, highlighting the differences in diagnosis, risk stratification and patient management, but also the still significant gaps in understanding the exact pathophysiology of these two phenotypes.
topic	mitral valve prolapse imaging mitral valve surgery
url	https://www.mdpi.com/2308-3425/8/2/23
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Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease

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