The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels
The effect of resveratrol on vasculature of diabetic animal is not defined. This study was aimed at evaluating how alloxan-induced diabetes alters the relaxation of the isolated rat renal artery (RA) to resveratrol and determining whether prolong hyperglycemia modifies the expression of potassium (K...
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doaj-fd036c3ca77646d3aa01a2b51e7293b12021-04-30T07:15:04ZengElsevierJournal of Functional Foods1756-46462019-01-0152266275The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channelsLjiljana Gojkovic-Bukarica0Jasmina Markovic-Lipkovski1Helmut Heinle2Sanja Cirovic3Jovana Rajkovic4Vladimir Djokic5Vladimir Zivanovic6Ana Bukarica7Radmila Novakovic8Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia; University Clinical Hospital Center “Dr Dragisa Misovic – Dedinje”, Heroja Milana Tepica 1, 11000 Belgrade, SerbiaInstitute of Pathology, Medical Faculty, University of Belgrade, Dr Subotica 1, 11129 Belgrade, SerbiaInstitute of Physiology, University of Tubingen, Gmelinstrase 5, D-72076 Tubingen, GermanyInstitute of Pathology, Medical Faculty, University of Belgrade, Dr Subotica 1, 11129 Belgrade, SerbiaInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, SerbiaInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, SerbiaUniversity Clinical Hospital Center “Dr Dragisa Misovic – Dedinje”, Heroja Milana Tepica 1, 11000 Belgrade, SerbiaInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, SerbiaInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia; Corresponding author.The effect of resveratrol on vasculature of diabetic animal is not defined. This study was aimed at evaluating how alloxan-induced diabetes alters the relaxation of the isolated rat renal artery (RA) to resveratrol and determining whether prolong hyperglycemia modifies the expression of potassium (K) channels in the wall of RA. Diabetes reduced the sensitivity to resveratrol in RA. According to K channel blocker affinity, it seems that different subtype of K channels were involved in the resveratrol-induced relaxation of RA of normal rats and only voltage-sensitive Kv1 channels took part in the resveratrol effect on the RA of diabetic rats. Endothelial dysfunction developed during diabetes led to down-regulation of the expression of almost all tested K channels, while up-regulation of Kv1.3 channel expression was only noticeable. Having in mind that Kv1.3 channels have a prominent role in insulin signalling, these results suggest renovascular protective effect of resveratrol in diabetes.http://www.sciencedirect.com/science/article/pii/S1756464618305772ResveratrolDiabetesRat renal arteryPotassium channels |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ljiljana Gojkovic-Bukarica Jasmina Markovic-Lipkovski Helmut Heinle Sanja Cirovic Jovana Rajkovic Vladimir Djokic Vladimir Zivanovic Ana Bukarica Radmila Novakovic |
spellingShingle |
Ljiljana Gojkovic-Bukarica Jasmina Markovic-Lipkovski Helmut Heinle Sanja Cirovic Jovana Rajkovic Vladimir Djokic Vladimir Zivanovic Ana Bukarica Radmila Novakovic The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels Journal of Functional Foods Resveratrol Diabetes Rat renal artery Potassium channels |
author_facet |
Ljiljana Gojkovic-Bukarica Jasmina Markovic-Lipkovski Helmut Heinle Sanja Cirovic Jovana Rajkovic Vladimir Djokic Vladimir Zivanovic Ana Bukarica Radmila Novakovic |
author_sort |
Ljiljana Gojkovic-Bukarica |
title |
The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels |
title_short |
The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels |
title_full |
The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels |
title_fullStr |
The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels |
title_full_unstemmed |
The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels |
title_sort |
red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: the role of potassium channels |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2019-01-01 |
description |
The effect of resveratrol on vasculature of diabetic animal is not defined. This study was aimed at evaluating how alloxan-induced diabetes alters the relaxation of the isolated rat renal artery (RA) to resveratrol and determining whether prolong hyperglycemia modifies the expression of potassium (K) channels in the wall of RA. Diabetes reduced the sensitivity to resveratrol in RA. According to K channel blocker affinity, it seems that different subtype of K channels were involved in the resveratrol-induced relaxation of RA of normal rats and only voltage-sensitive Kv1 channels took part in the resveratrol effect on the RA of diabetic rats. Endothelial dysfunction developed during diabetes led to down-regulation of the expression of almost all tested K channels, while up-regulation of Kv1.3 channel expression was only noticeable. Having in mind that Kv1.3 channels have a prominent role in insulin signalling, these results suggest renovascular protective effect of resveratrol in diabetes. |
topic |
Resveratrol Diabetes Rat renal artery Potassium channels |
url |
http://www.sciencedirect.com/science/article/pii/S1756464618305772 |
work_keys_str_mv |
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