Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury
Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin a...
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doaj-fd099229d6194811a724d9f3da8e64c92020-11-25T01:44:43ZengMDPI AGJournal of Clinical Medicine2077-03832019-01-01817410.3390/jcm8010074jcm8010074Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney InjuryJia-Jin Chen0Pei-Chun Fan1George Kou2Su-Wei Chang3Yi-Ting Chen4Cheng-Chia Lee5Chih-Hsiang Chang6Department of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanClinical Informatics and Medical Statistics Research Center, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDepartment of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanBackground: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its diagnostic performance in different AKI criteria and study populations. Method: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Embase, and the Cochrane database up to September 2018. The diagnostic performance of urinary calprotectin (sensitivity, specificity, predictive ratio, and cutoff point) was extracted and evaluated. Result: This study included six studies with a total of 502 patients. The pooled sensitivity and specificity were 0.90 and 0.93, respectively. The pooled positive likelihood ratio (LR) was 15.15, and the negative LR was 0.11. The symmetric summary receiver operating characteristic (symmetric SROC) with pooled diagnostic accuracy was 0.9667. The relative diagnostic odds ratio (RDOC) of the adult to pediatric population and RDOCs of different acute kidney injury criteria showed no significant difference in their diagnostic accuracy. Conclusion: Urinary calprotectin is a good diagnostic tool for the discrimination of intrinsic and prerenal AKI under careful inspection after exclusion of urinary tract infection and urogenital malignancies. Its performance is not affected by different AKI criteria and adult or pediatric populations.http://www.mdpi.com/2077-0383/8/1/74urine calprotectinacute kidney injuryintrinsic renal injury |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jia-Jin Chen Pei-Chun Fan George Kou Su-Wei Chang Yi-Ting Chen Cheng-Chia Lee Chih-Hsiang Chang |
spellingShingle |
Jia-Jin Chen Pei-Chun Fan George Kou Su-Wei Chang Yi-Ting Chen Cheng-Chia Lee Chih-Hsiang Chang Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury Journal of Clinical Medicine urine calprotectin acute kidney injury intrinsic renal injury |
author_facet |
Jia-Jin Chen Pei-Chun Fan George Kou Su-Wei Chang Yi-Ting Chen Cheng-Chia Lee Chih-Hsiang Chang |
author_sort |
Jia-Jin Chen |
title |
Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury |
title_short |
Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury |
title_full |
Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury |
title_fullStr |
Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury |
title_full_unstemmed |
Meta-Analysis: Urinary Calprotectin for Discrimination of Intrinsic and Prerenal Acute Kidney Injury |
title_sort |
meta-analysis: urinary calprotectin for discrimination of intrinsic and prerenal acute kidney injury |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-01-01 |
description |
Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its diagnostic performance in different AKI criteria and study populations. Method: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Embase, and the Cochrane database up to September 2018. The diagnostic performance of urinary calprotectin (sensitivity, specificity, predictive ratio, and cutoff point) was extracted and evaluated. Result: This study included six studies with a total of 502 patients. The pooled sensitivity and specificity were 0.90 and 0.93, respectively. The pooled positive likelihood ratio (LR) was 15.15, and the negative LR was 0.11. The symmetric summary receiver operating characteristic (symmetric SROC) with pooled diagnostic accuracy was 0.9667. The relative diagnostic odds ratio (RDOC) of the adult to pediatric population and RDOCs of different acute kidney injury criteria showed no significant difference in their diagnostic accuracy. Conclusion: Urinary calprotectin is a good diagnostic tool for the discrimination of intrinsic and prerenal AKI under careful inspection after exclusion of urinary tract infection and urogenital malignancies. Its performance is not affected by different AKI criteria and adult or pediatric populations. |
topic |
urine calprotectin acute kidney injury intrinsic renal injury |
url |
http://www.mdpi.com/2077-0383/8/1/74 |
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