HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia
Introduction. Specific molecular epidemic features of HIV infection in Tyumen Oblast (TO), Russia, were studied. Methods. The genome sequences encoding HIV-1 protease-reverse transcriptase, integrase, and major envelope protein were examined for 72 HIV-1 specimens isolated from the TO resident infec...
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doaj-fd09e171cffa4908a9a40d92ac0666292020-11-24T22:14:42ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/24962802496280HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, RussiaNatalya M. Gashnikova0Ekaterina M. Astakhova1Mariya P. Gashnikova2Evgeniy F. Bocharov3Svetlana V. Petrova4Olga A. Pun’ko5Alexander V. Popkov6Aleksey V. Totmenin7State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast 630559, RussiaState Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast 630559, RussiaState Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast 630559, RussiaState Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast 630559, RussiaTyumen Regional Center for Prevention and Control of AIDS and Infectious Diseases, Ul. Novaya 2, Tyumen, RussiaTyumen Regional Center for Prevention and Control of AIDS and Infectious Diseases, Ul. Novaya 2, Tyumen, RussiaTyumen Regional Center for Prevention and Control of AIDS and Infectious Diseases, Ul. Novaya 2, Tyumen, RussiaState Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast 630559, RussiaIntroduction. Specific molecular epidemic features of HIV infection in Tyumen Oblast (TO), Russia, were studied. Methods. The genome sequences encoding HIV-1 protease-reverse transcriptase, integrase, and major envelope protein were examined for 72 HIV-1 specimens isolated from the TO resident infected in 2000–2015. Results. The recorded prevalence of HIV-1 subtype A (A1) is 93.1%; HIV-1 subtype B continues to circulate in MSM risk group (1.4%). Solitary instances of HIV-1 recombinant forms, CRF63_02A1 (1.4%) and CRF03_AB (1.4%), were detected as well as two cases of HIV-1 URF63_A1 (2.8%). Phylogenetic analysis showed no HIV-1 clustering according to the duration of infection and risk groups but revealed different epidemic networks confirming that HIV infection spread within local epidemic foci. A high incidence of CXCR4-tropic HIV-1 variants and a higher rate of secondary mutations influencing the virus fitness (K20R, L10V, and I) are observed among the virus specimens isolated from newly infected individuals. Conclusions. The current HIV-1 epidemic in TO develops within the local epidemic networks. Similar to the previous period, HIV-1 subtype A is predominant in TO with sporadic cases of importation of HIV-1 recombinant forms circulating in adjacent areas.http://dx.doi.org/10.1155/2016/2496280 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Natalya M. Gashnikova Ekaterina M. Astakhova Mariya P. Gashnikova Evgeniy F. Bocharov Svetlana V. Petrova Olga A. Pun’ko Alexander V. Popkov Aleksey V. Totmenin |
spellingShingle |
Natalya M. Gashnikova Ekaterina M. Astakhova Mariya P. Gashnikova Evgeniy F. Bocharov Svetlana V. Petrova Olga A. Pun’ko Alexander V. Popkov Aleksey V. Totmenin HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia BioMed Research International |
author_facet |
Natalya M. Gashnikova Ekaterina M. Astakhova Mariya P. Gashnikova Evgeniy F. Bocharov Svetlana V. Petrova Olga A. Pun’ko Alexander V. Popkov Aleksey V. Totmenin |
author_sort |
Natalya M. Gashnikova |
title |
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia |
title_short |
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia |
title_full |
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia |
title_fullStr |
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia |
title_full_unstemmed |
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia |
title_sort |
hiv-1 epidemiology, genetic diversity, and primary drug resistance in the tyumen oblast, russia |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Introduction. Specific molecular epidemic features of HIV infection in Tyumen Oblast (TO), Russia, were studied. Methods. The genome sequences encoding HIV-1 protease-reverse transcriptase, integrase, and major envelope protein were examined for 72 HIV-1 specimens isolated from the TO resident infected in 2000–2015. Results. The recorded prevalence of HIV-1 subtype A (A1) is 93.1%; HIV-1 subtype B continues to circulate in MSM risk group (1.4%). Solitary instances of HIV-1 recombinant forms, CRF63_02A1 (1.4%) and CRF03_AB (1.4%), were detected as well as two cases of HIV-1 URF63_A1 (2.8%). Phylogenetic analysis showed no HIV-1 clustering according to the duration of infection and risk groups but revealed different epidemic networks confirming that HIV infection spread within local epidemic foci. A high incidence of CXCR4-tropic HIV-1 variants and a higher rate of secondary mutations influencing the virus fitness (K20R, L10V, and I) are observed among the virus specimens isolated from newly infected individuals. Conclusions. The current HIV-1 epidemic in TO develops within the local epidemic networks. Similar to the previous period, HIV-1 subtype A is predominant in TO with sporadic cases of importation of HIV-1 recombinant forms circulating in adjacent areas. |
url |
http://dx.doi.org/10.1155/2016/2496280 |
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