High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

Abstract Background Non-caloric artificial sweeteners (NCAS) are widely used as a substitute for dietary sugars to control body weight or glycemia. Paradoxically, some interventional studies in humans and rodents have shown unfavorable changes in glucose homeostasis in response to NCAS consumption....

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Bibliographic Details
Main Authors: Joan Serrano, Kathleen R. Smith, Audra L. Crouch, Vandana Sharma, Fanchao Yi, Veronika Vargova, Traci E. LaMoia, Lydia M. Dupont, Vanida Serna, Fenfen Tang, Laisa Gomes-Dias, Joshua J. Blakeslee, Emmanuel Hatzakis, Scott N. Peterson, Matthew Anderson, Richard E. Pratley, George A. Kyriazis
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Microbiome
Subjects:
Artificial sweeteners
Saccharin
Sweet taste receptors
Gut microbiota
Glucose intolerance
Short-chain fatty acids
Online Access:https://doi.org/10.1186/s40168-020-00976-w

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