Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1
Repair of DNA lesions through homologous recombination promotes the establishment of stable chromosomal interactions. Multiple helicases, topoisomerases and structure-selective endonucleases (SSEs) act upon recombining joint molecules (JMs) to disengage chromosomal connections and safeguard chromoso...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-07-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00253/full |
id |
doaj-fd11d6ed11954f7ea7e9a55b8203d0a9 |
---|---|
record_format |
Article |
spelling |
doaj-fd11d6ed11954f7ea7e9a55b8203d0a92020-11-24T23:00:47ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-07-01610.3389/fgene.2015.00253151510Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1Miguel eGonzalez Blanco0Joao eMatos1University of Santiago de CompostelaETH - ZurichRepair of DNA lesions through homologous recombination promotes the establishment of stable chromosomal interactions. Multiple helicases, topoisomerases and structure-selective endonucleases (SSEs) act upon recombining joint molecules (JMs) to disengage chromosomal connections and safeguard chromosome segregation. Recent studies on two conserved SSEs -MUS81 and Yen1/GEN1- uncovered multiple layers of regulation that operate to carefully tailor JM-processing according to specific cellular needs. Temporal restriction of SSE function imposes a hierarchy in pathway usage that ensures efficient JM processing while minimizing reciprocal exchanges between the recombining DNAs. Whereas a conserved strategy of fine-tuning SSE functions exists in different model systems, the precise molecular mechanisms to implement it appear to be significantly different. Here, we summarize the current knowledge on the cellular switches that are in place to control MUS81 and Yen1/GEN1 functions.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00253/fullDNA RepairreplicationrecombinationCdk1Cdc5Cdc14 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miguel eGonzalez Blanco Joao eMatos |
spellingShingle |
Miguel eGonzalez Blanco Joao eMatos Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 Frontiers in Genetics DNA Repair replication recombination Cdk1 Cdc5 Cdc14 |
author_facet |
Miguel eGonzalez Blanco Joao eMatos |
author_sort |
Miguel eGonzalez Blanco |
title |
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 |
title_short |
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 |
title_full |
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 |
title_fullStr |
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 |
title_full_unstemmed |
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 |
title_sort |
hold your horsses: controlling structure-selective endonucleases mus81 and yen1/gen1 |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2015-07-01 |
description |
Repair of DNA lesions through homologous recombination promotes the establishment of stable chromosomal interactions. Multiple helicases, topoisomerases and structure-selective endonucleases (SSEs) act upon recombining joint molecules (JMs) to disengage chromosomal connections and safeguard chromosome segregation. Recent studies on two conserved SSEs -MUS81 and Yen1/GEN1- uncovered multiple layers of regulation that operate to carefully tailor JM-processing according to specific cellular needs. Temporal restriction of SSE function imposes a hierarchy in pathway usage that ensures efficient JM processing while minimizing reciprocal exchanges between the recombining DNAs. Whereas a conserved strategy of fine-tuning SSE functions exists in different model systems, the precise molecular mechanisms to implement it appear to be significantly different. Here, we summarize the current knowledge on the cellular switches that are in place to control MUS81 and Yen1/GEN1 functions. |
topic |
DNA Repair replication recombination Cdk1 Cdc5 Cdc14 |
url |
http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00253/full |
work_keys_str_mv |
AT miguelegonzalezblanco holdyourhorssescontrollingstructureselectiveendonucleasesmus81andyen1gen1 AT joaoematos holdyourhorssescontrollingstructureselectiveendonucleasesmus81andyen1gen1 |
_version_ |
1725641269389033472 |