Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention...
Main Authors: | Ines Martinez-Corral, Yan Zhang, Milena Petkova, Henrik Ortsäter, Sofie Sjöberg, Sandra D. Castillo, Pascal Brouillard, Louis Libbrecht, Dieter Saur, Mariona Graupera, Kari Alitalo, Laurence Boon, Miikka Vikkula, Taija Mäkinen |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-16496-y |
Similar Items
-
Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations
by: Pascal Brouillard, et al.
Published: (2021-06-01) -
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
by: Lukas Stanczuk, et al.
Published: (2015-03-01) -
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
by: Sawan Kumar Jha, et al.
Published: (2017-07-01) -
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
by: Yan Zhang, et al.
Published: (2018-04-01) -
PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations.
by: Hannah Blesinger, et al.
Published: (2018-01-01)