Intra-Tumoral Angiogenesis Is Associated with Inflammation, Immune Reaction and Metastatic Recurrence in Breast Cancer

Intra-Tumoral Angiogenesis Is Associated with Inflammation, Immune Reaction and Metastatic Recurrence in Breast Cancer

Angiogenesis is one of the hallmarks of cancer. We hypothesized that intra-tumoral angiogenesis correlates with inflammation and metastasis in breast cancer patients. To test this hypothesis, we generated an angiogenesis pathway score using gene set variation analysis and analyzed the tumor transcri...

Full description

Bibliographic Details
Main Authors:	Masanori Oshi, Stephanie Newman, Yoshihisa Tokumaru, Li Yan, Ryusei Matsuyama, Itaru Endo, Masayuki Nagahashi, Kazuaki Takabe
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	International Journal of Molecular Sciences
Subjects:	angiogenesis breast cancer epithelial-mesenchymal transition gene set metastatic recurrence sphingosine-1-phosphate
Online Access:	https://www.mdpi.com/1422-0067/21/18/6708

Similar Items

Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology
by: Rolando Campanella, et al.
Published: (2020-01-01)

Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation
by: Masayo Aoki, et al.
Published: (2019-07-01)

The Synergic Effects of Flow and Sphingosine 1-Phosphate on Sprouting Angiogenesis Into Three-Dimensional Collagen Matrices
by: Kang, Ho Jin
Published: (2012)

Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation
by: Shahzad Nawaz Syed, et al.
Published: (2019-07-01)

Degree of Early Estrogen Response Predict Survival after Endocrine Therapy in Primary and Metastatic ER-Positive Breast Cancer
by: Masanori Oshi, et al.
Published: (2020-11-01)

Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
by: Qiu-Luo Liu, et al.
Published: (2021-04-01)

Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study
by: Roberta Sferra, et al.
Published: (2018-07-01)

Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism
by: Xiaolan You, et al.
Published: (2018-11-01)

The role of angiogenesis blockers in the treatment of metastatic ovarian cancer
by: M R Oganian, et al.
Published: (2013-12-01)

Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple-Negative Subtype of Breast Cancer Patients
by: Masanori Oshi, et al.
Published: (2020-01-01)

MiR-9 Promotes Angiogenesis via Targeting on Sphingosine-1- Phosphate Receptor 1
by: Xinghong Yao, et al.
Published: (2020-08-01)

Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis
by: Kazuaki Takabe, et al.
Published: (2013-07-01)

Export of sphingosine-1-phosphate and cancer progression
by: Kazuaki Takabe, et al.
Published: (2014-09-01)

Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
by: Sara Grassi, et al.
Published: (2019-07-01)

Targeting <i>S1PR1</i> May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma
by: Chin-Li Chen, et al.
Published: (2021-09-01)

The predictive value of serum S1P and STIM1 levels after PCI for instent restenosis and their correlation with angiogenesis and inflammatory response
by: Fang Wang, et al.
Published: (2017-07-01)

Annexin A1 Expression Is Associated with Epithelial–Mesenchymal Transition (EMT), Cell Proliferation, Prognosis, and Drug Response in Pancreatic Cancer
by: Masanori Oshi, et al.
Published: (2021-03-01)

The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer
by: Masanori Oshi, et al.
Published: (2020-07-01)

Effect of PACAP on Hypoxia-Induced Angiogenesis and Epithelial–Mesenchymal Transition in Glioblastoma
by: Grazia Maugeri, et al.
Published: (2021-08-01)

Plasmacytoid Dendritic Cell (pDC) Infiltration Correlate with Tumor Infiltrating Lymphocytes, Cancer Immunity, and Better Survival in Triple Negative Breast Cancer (TNBC) More Strongly than Conventional Dendritic Cell (cDC)
by: Masanori Oshi, et al.
Published: (2020-11-01)

ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer
by: Masanori Oshi, et al.
Published: (2020-09-01)

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis
by: Cynthia Weigel, et al.
Published: (2020-08-01)

Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers
by: Jamie R. Friedman, et al.
Published: (2019-10-01)

High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer
by: Masanori Oshi, et al.
Published: (2020-12-01)

A Novel Three-Gene Score as a Predictive Biomarker for Pathologically Complete Response after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
by: Masanori Oshi, et al.
Published: (2021-05-01)

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives
by: Alexandra Lucaciu, et al.
Published: (2020-06-01)

Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients
by: Suchittra SAMUHASANEETO, et al.
Published: (2016-06-01)

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
by: Michael Maceyka, et al.
Published: (2009-01-01)

Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson’s Disease
by: Joanna A. Motyl, et al.
Published: (2021-06-01)

The Anti-Infectious Role of Sphingosine in Microbial Diseases
by: Yuqing Wu, et al.
Published: (2021-05-01)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
by: Guangmeng Xu, et al.
Published: (2021-09-01)

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies1
by: Nicole O'Brien, et al.
Published: (2009-11-01)

Study on the correlation of helicobacter pylori infection with proliferation, invasion and angiogenesis molecules in gastric cancer tissue
by: Sa-Mei Lv, et al.
Published: (2016-08-01)

Sphingolipids as Emerging Mediators in Retina Degeneration
by: M. Victoria Simón, et al.
Published: (2019-06-01)

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
by: Alexandra Lucaciu, et al.
Published: (2020-08-01)

CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer
by: Masanori Oshi, et al.
Published: (2020-09-01)

High G2M Pathway Score Pancreatic Cancer is Associated with Worse Survival, Particularly after Margin-Positive (R1 or R2) Resection
by: Masanori Oshi, et al.
Published: (2020-10-01)

Role of Sphingosine-1-Phosphate in Mast Cell Functions and Asthma and Its Regulation by Non-Coding RNA
by: Rohit Saluja, et al.
Published: (2017-05-01)

Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease[S]
by: Julie D. Saba
Published: (2019-03-01)

Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors
by: Congdon, Molly D.
Published: (2018)