Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients
Traumatic brain injury (TBI) is a worldwide core public health problem affecting mostly young male subjects. An alarming increase in incidence has turned TBI into a leading cause of morbidity and mortality in young adults as well as a tremendous resource burden on the health and welfare sector. Horm...
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Format: | Article |
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Frontiers Media S.A.
2018-02-01
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Series: | Frontiers in Endocrinology |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2018.00029/full |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandre Hohl Alexandre Hohl Fernando Areas Zanela Gabriela Ghisi Marcelo Fernando Ronsoni Marcelo Fernando Ronsoni Alexandre Paim Diaz Alexandre Paim Diaz Marcelo Liborio Schwarzbold Marcelo Liborio Schwarzbold Alcir Luiz Dafre Alcir Luiz Dafre Benjamin Reddi Benjamin Reddi Kátia Lin Kátia Lin Felipe Dal Pizzol Felipe Dal Pizzol Roger Walz Roger Walz |
spellingShingle |
Alexandre Hohl Alexandre Hohl Fernando Areas Zanela Gabriela Ghisi Marcelo Fernando Ronsoni Marcelo Fernando Ronsoni Alexandre Paim Diaz Alexandre Paim Diaz Marcelo Liborio Schwarzbold Marcelo Liborio Schwarzbold Alcir Luiz Dafre Alcir Luiz Dafre Benjamin Reddi Benjamin Reddi Kátia Lin Kátia Lin Felipe Dal Pizzol Felipe Dal Pizzol Roger Walz Roger Walz Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients Frontiers in Endocrinology traumatic brain injury gonadotrophic axis luteinizing hormone testosterone prognosis |
author_facet |
Alexandre Hohl Alexandre Hohl Fernando Areas Zanela Gabriela Ghisi Marcelo Fernando Ronsoni Marcelo Fernando Ronsoni Alexandre Paim Diaz Alexandre Paim Diaz Marcelo Liborio Schwarzbold Marcelo Liborio Schwarzbold Alcir Luiz Dafre Alcir Luiz Dafre Benjamin Reddi Benjamin Reddi Kátia Lin Kátia Lin Felipe Dal Pizzol Felipe Dal Pizzol Roger Walz Roger Walz |
author_sort |
Alexandre Hohl |
title |
Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients |
title_short |
Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients |
title_full |
Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients |
title_fullStr |
Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients |
title_full_unstemmed |
Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients |
title_sort |
luteinizing hormone and testosterone levels during acute phase of severe traumatic brain injury: prognostic implications for adult male patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2018-02-01 |
description |
Traumatic brain injury (TBI) is a worldwide core public health problem affecting mostly young male subjects. An alarming increase in incidence has turned TBI into a leading cause of morbidity and mortality in young adults as well as a tremendous resource burden on the health and welfare sector. Hormone dysfunction is highly prevalent during the acute phase of severe TBI. In particular, investigation of the luteinizing hormone (LH) and testosterone levels during the acute phase of severe TBI in male has identified a high incidence of low testosterone levels in male patients (36.5–100%) but the prognostic significance of which remains controversial. Two independent studies showed that normal or elevated levels of LH levels earlier during hospitalization are significantly associated with higher mortality/morbidity. The association between LH levels and prognosis was independent of other predictive variables such as neuroimaging, admission Glasgow coma scale, and pupillary reaction. The possible mechanisms underlying this association and further research directions in this field are discussed. Overall, current data suggest that LH levels during the acute phase of TBI might contribute to accurate prognostication and further prospective multicentric studies are required to develop more sophisticated predictive models incorporating biomarkers such as LH in the quest for accurate outcome prediction following TBI. Moreover, the potential therapeutic benefits of modulating LH during the acute phase of TBI warrant investigation. |
topic |
traumatic brain injury gonadotrophic axis luteinizing hormone testosterone prognosis |
url |
http://journal.frontiersin.org/article/10.3389/fendo.2018.00029/full |
work_keys_str_mv |
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doaj-fd1e7c6d78504f7495223ec797a269092020-11-24T20:54:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-02-01910.3389/fendo.2018.00029328727Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male PatientsAlexandre Hohl0Alexandre Hohl1Fernando Areas Zanela2Gabriela Ghisi3Marcelo Fernando Ronsoni4Marcelo Fernando Ronsoni5Alexandre Paim Diaz6Alexandre Paim Diaz7Marcelo Liborio Schwarzbold8Marcelo Liborio Schwarzbold9Alcir Luiz Dafre10Alcir Luiz Dafre11Benjamin Reddi12Benjamin Reddi13Kátia Lin14Kátia Lin15Felipe Dal Pizzol16Felipe Dal Pizzol17Roger Walz18Roger Walz19Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Endocrinologia e Metabologia, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Endocrinologia e Metabologia, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Endocrinologia e Metabologia, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Psiquiatria, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Psiquiatria, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilDepartamento de Bioquímica, Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilIntensive Care Unit, Royal Adelaide Hospital, Adelaide, SA, AustraliaSchool of Medicine, University of Adelaide, Adelaide, SA, AustraliaCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Neurologia, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilLaboratório de Fisiopatologia Experimental, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, BrazilCentro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilServiço de Neurologia, Departamento de Clínica Médica, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, BrazilTraumatic brain injury (TBI) is a worldwide core public health problem affecting mostly young male subjects. An alarming increase in incidence has turned TBI into a leading cause of morbidity and mortality in young adults as well as a tremendous resource burden on the health and welfare sector. Hormone dysfunction is highly prevalent during the acute phase of severe TBI. In particular, investigation of the luteinizing hormone (LH) and testosterone levels during the acute phase of severe TBI in male has identified a high incidence of low testosterone levels in male patients (36.5–100%) but the prognostic significance of which remains controversial. Two independent studies showed that normal or elevated levels of LH levels earlier during hospitalization are significantly associated with higher mortality/morbidity. The association between LH levels and prognosis was independent of other predictive variables such as neuroimaging, admission Glasgow coma scale, and pupillary reaction. The possible mechanisms underlying this association and further research directions in this field are discussed. Overall, current data suggest that LH levels during the acute phase of TBI might contribute to accurate prognostication and further prospective multicentric studies are required to develop more sophisticated predictive models incorporating biomarkers such as LH in the quest for accurate outcome prediction following TBI. Moreover, the potential therapeutic benefits of modulating LH during the acute phase of TBI warrant investigation.http://journal.frontiersin.org/article/10.3389/fendo.2018.00029/fulltraumatic brain injurygonadotrophic axisluteinizing hormonetestosteroneprognosis |