Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estroge...
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2017-06-01
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doaj-fd298ffaee30484aa230116bab58f4f52020-11-25T03:32:08ZengChina Medical UniversityBioMedicine2211-80392017-06-01721110.1051/bmdcn/2017070204bmdcn2017070204Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptorsAsokan Shibu MarthandamKuo Wei-WenKuo Chia-HuaDay Cecilia-HsuanShen Chia-YaoChung Li-ChinLai Chao-HungPan Lung-FaVijaya Padma V.Huang Chih-YangThe 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults. In this review, we focus on the estrogen and ERs mediated signaling pathways in cardiomyocytes that determines cardio-protection against various stresses and further discuss the clinical implication of ERs and phytoestrogens. Further we provide some insights on phytoeostrogens which may play as alternatives in estrogen replacement therapies.https://doi.org/10.1051/bmdcn/201707020417 Beta-estradiolEstrogen receptor-alphaEstrogen receptor-betaPhytoestrogensSurvival signallingApoptosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Asokan Shibu Marthandam Kuo Wei-Wen Kuo Chia-Hua Day Cecilia-Hsuan Shen Chia-Yao Chung Li-Chin Lai Chao-Hung Pan Lung-Fa Vijaya Padma V. Huang Chih-Yang |
spellingShingle |
Asokan Shibu Marthandam Kuo Wei-Wen Kuo Chia-Hua Day Cecilia-Hsuan Shen Chia-Yao Chung Li-Chin Lai Chao-Hung Pan Lung-Fa Vijaya Padma V. Huang Chih-Yang Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors BioMedicine 17 Beta-estradiol Estrogen receptor-alpha Estrogen receptor-beta Phytoestrogens Survival signalling Apoptosis |
author_facet |
Asokan Shibu Marthandam Kuo Wei-Wen Kuo Chia-Hua Day Cecilia-Hsuan Shen Chia-Yao Chung Li-Chin Lai Chao-Hung Pan Lung-Fa Vijaya Padma V. Huang Chih-Yang |
author_sort |
Asokan Shibu Marthandam |
title |
Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors |
title_short |
Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors |
title_full |
Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors |
title_fullStr |
Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors |
title_full_unstemmed |
Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors |
title_sort |
potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors |
publisher |
China Medical University |
series |
BioMedicine |
issn |
2211-8039 |
publishDate |
2017-06-01 |
description |
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults. In this review, we focus on the estrogen and ERs mediated signaling pathways in cardiomyocytes that determines cardio-protection against various stresses and further discuss the clinical implication of ERs and phytoestrogens. Further we provide some insights on phytoeostrogens which may play as alternatives in estrogen replacement therapies. |
topic |
17 Beta-estradiol Estrogen receptor-alpha Estrogen receptor-beta Phytoestrogens Survival signalling Apoptosis |
url |
https://doi.org/10.1051/bmdcn/2017070204 |
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