A novel role for the actin-binding protein drebrin in regulating opiate addiction
The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is...
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Nature Publishing Group
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12122-8 |
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doaj-fd3986183cd145e696e221b400cee2512021-05-11T11:39:31ZengNature Publishing GroupNature Communications2041-17232019-09-0110111110.1038/s41467-019-12122-8A novel role for the actin-binding protein drebrin in regulating opiate addictionJennifer A. Martin0Craig T. Werner1Swarup Mitra2Ping Zhong3Zi-Jun Wang4Pedro H. Gobira5Andrew. F. Stewart6Jay Zhang7Kyra Erias8Justin N. Siemian9Devin Hagarty10Lauren E. Mueller11Rachael L. Neve12Jun-Xu Li13Ramesh Chandra14Karen C. Dietz15Mary Kay Lobo16Amy M. Gancarz17Zhen Yan18David M. Dietz19Department of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Physiology and Biophysics, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Psychology, California State University BakersfieldDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloGene Delivery Technology Core, Massachusetts General HospitalDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Anatomy and Neurobiology, University of Maryland School of MedicineDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloDepartment of Anatomy and Neurobiology, University of Maryland School of MedicineDepartment of Psychology, California State University BakersfieldDepartment of Physiology and Biophysics, The State University of New York at BuffaloDepartment of Pharmacology and Toxicology, Program in Neuroscience, Research Institute on Addictions, The State University of New York at BuffaloThe underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is shown to be transcriptionally repressed by the histone modifier HDAC2, and that overexpression of drebrin is sufficient to decrease drug seeking and increase dendritic spine densityhttps://doi.org/10.1038/s41467-019-12122-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jennifer A. Martin Craig T. Werner Swarup Mitra Ping Zhong Zi-Jun Wang Pedro H. Gobira Andrew. F. Stewart Jay Zhang Kyra Erias Justin N. Siemian Devin Hagarty Lauren E. Mueller Rachael L. Neve Jun-Xu Li Ramesh Chandra Karen C. Dietz Mary Kay Lobo Amy M. Gancarz Zhen Yan David M. Dietz |
| spellingShingle |
Jennifer A. Martin Craig T. Werner Swarup Mitra Ping Zhong Zi-Jun Wang Pedro H. Gobira Andrew. F. Stewart Jay Zhang Kyra Erias Justin N. Siemian Devin Hagarty Lauren E. Mueller Rachael L. Neve Jun-Xu Li Ramesh Chandra Karen C. Dietz Mary Kay Lobo Amy M. Gancarz Zhen Yan David M. Dietz A novel role for the actin-binding protein drebrin in regulating opiate addiction Nature Communications |
| author_facet |
Jennifer A. Martin Craig T. Werner Swarup Mitra Ping Zhong Zi-Jun Wang Pedro H. Gobira Andrew. F. Stewart Jay Zhang Kyra Erias Justin N. Siemian Devin Hagarty Lauren E. Mueller Rachael L. Neve Jun-Xu Li Ramesh Chandra Karen C. Dietz Mary Kay Lobo Amy M. Gancarz Zhen Yan David M. Dietz |
| author_sort |
Jennifer A. Martin |
| title |
A novel role for the actin-binding protein drebrin in regulating opiate addiction |
| title_short |
A novel role for the actin-binding protein drebrin in regulating opiate addiction |
| title_full |
A novel role for the actin-binding protein drebrin in regulating opiate addiction |
| title_fullStr |
A novel role for the actin-binding protein drebrin in regulating opiate addiction |
| title_full_unstemmed |
A novel role for the actin-binding protein drebrin in regulating opiate addiction |
| title_sort |
novel role for the actin-binding protein drebrin in regulating opiate addiction |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is shown to be transcriptionally repressed by the histone modifier HDAC2, and that overexpression of drebrin is sufficient to decrease drug seeking and increase dendritic spine density |
| url |
https://doi.org/10.1038/s41467-019-12122-8 |
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