The induction and function of the anti-inflammatory fate of TH17 cells
CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simulta...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17097-5 |
| id |
doaj-fd3bdc3cbb8644b4bdee048b5254c9a1 |
|---|---|
| record_format |
Article |
| spelling |
doaj-fd3bdc3cbb8644b4bdee048b5254c9a12021-07-04T11:47:37ZengNature Publishing GroupNature Communications2041-17232020-07-0111111310.1038/s41467-020-17097-5The induction and function of the anti-inflammatory fate of TH17 cellsHao Xu0Theodora Agalioti1Jun Zhao2Babett Steglich3Ramez Wahib4Maria Carolina Amezcua Vesely5Piotr Bielecki6Will Bailis7Ruaidhri Jackson8Daniel Perez9Jakob Izbicki10Paula Licona-Limón11Vesa Kaartinen12Jens Geginat13Enric Esplugues14Eva Tolosa15Samuel Huber16Richard A. Flavell17Nicola Gagliani18Department of Immunobiology, School of Medicine, Yale UniversityDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of Immunobiology, School of Medicine, Yale UniversityI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of Immunobiology, School of Medicine, Yale UniversityDepartment of Immunobiology, School of Medicine, Yale UniversityDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Immunobiology, School of Medicine, Yale UniversityDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de MéxicoBiologic and Material Sciences, University of MichiganINGM-National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF)Institute of Immunology, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of Immunobiology, School of Medicine, Yale UniversityDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfCD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simultaneously dampens protective immunity against S. aureus.https://doi.org/10.1038/s41467-020-17097-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hao Xu Theodora Agalioti Jun Zhao Babett Steglich Ramez Wahib Maria Carolina Amezcua Vesely Piotr Bielecki Will Bailis Ruaidhri Jackson Daniel Perez Jakob Izbicki Paula Licona-Limón Vesa Kaartinen Jens Geginat Enric Esplugues Eva Tolosa Samuel Huber Richard A. Flavell Nicola Gagliani |
| spellingShingle |
Hao Xu Theodora Agalioti Jun Zhao Babett Steglich Ramez Wahib Maria Carolina Amezcua Vesely Piotr Bielecki Will Bailis Ruaidhri Jackson Daniel Perez Jakob Izbicki Paula Licona-Limón Vesa Kaartinen Jens Geginat Enric Esplugues Eva Tolosa Samuel Huber Richard A. Flavell Nicola Gagliani The induction and function of the anti-inflammatory fate of TH17 cells Nature Communications |
| author_facet |
Hao Xu Theodora Agalioti Jun Zhao Babett Steglich Ramez Wahib Maria Carolina Amezcua Vesely Piotr Bielecki Will Bailis Ruaidhri Jackson Daniel Perez Jakob Izbicki Paula Licona-Limón Vesa Kaartinen Jens Geginat Enric Esplugues Eva Tolosa Samuel Huber Richard A. Flavell Nicola Gagliani |
| author_sort |
Hao Xu |
| title |
The induction and function of the anti-inflammatory fate of TH17 cells |
| title_short |
The induction and function of the anti-inflammatory fate of TH17 cells |
| title_full |
The induction and function of the anti-inflammatory fate of TH17 cells |
| title_fullStr |
The induction and function of the anti-inflammatory fate of TH17 cells |
| title_full_unstemmed |
The induction and function of the anti-inflammatory fate of TH17 cells |
| title_sort |
induction and function of the anti-inflammatory fate of th17 cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-07-01 |
| description |
CD4+ T helper cells producing IL-17A (TH17 cells) can take on pathogenic or anti-inflammatory functions in context-specific manners. Here the authors show that the anti-inflammatory fate of TH17 cells contributes, via TGF-β signaling and induction of IL-10, to host immune tolerance, but also simultaneously dampens protective immunity against S. aureus. |
| url |
https://doi.org/10.1038/s41467-020-17097-5 |
| work_keys_str_mv |
AT haoxu theinductionandfunctionoftheantiinflammatoryfateofth17cells AT theodoraagalioti theinductionandfunctionoftheantiinflammatoryfateofth17cells AT junzhao theinductionandfunctionoftheantiinflammatoryfateofth17cells AT babettsteglich theinductionandfunctionoftheantiinflammatoryfateofth17cells AT ramezwahib theinductionandfunctionoftheantiinflammatoryfateofth17cells AT mariacarolinaamezcuavesely theinductionandfunctionoftheantiinflammatoryfateofth17cells AT piotrbielecki theinductionandfunctionoftheantiinflammatoryfateofth17cells AT willbailis theinductionandfunctionoftheantiinflammatoryfateofth17cells AT ruaidhrijackson theinductionandfunctionoftheantiinflammatoryfateofth17cells AT danielperez theinductionandfunctionoftheantiinflammatoryfateofth17cells AT jakobizbicki theinductionandfunctionoftheantiinflammatoryfateofth17cells AT paulaliconalimon theinductionandfunctionoftheantiinflammatoryfateofth17cells AT vesakaartinen theinductionandfunctionoftheantiinflammatoryfateofth17cells AT jensgeginat theinductionandfunctionoftheantiinflammatoryfateofth17cells AT enricesplugues theinductionandfunctionoftheantiinflammatoryfateofth17cells AT evatolosa theinductionandfunctionoftheantiinflammatoryfateofth17cells AT samuelhuber theinductionandfunctionoftheantiinflammatoryfateofth17cells AT richardaflavell theinductionandfunctionoftheantiinflammatoryfateofth17cells AT nicolagagliani theinductionandfunctionoftheantiinflammatoryfateofth17cells AT haoxu inductionandfunctionoftheantiinflammatoryfateofth17cells AT theodoraagalioti inductionandfunctionoftheantiinflammatoryfateofth17cells AT junzhao inductionandfunctionoftheantiinflammatoryfateofth17cells AT babettsteglich inductionandfunctionoftheantiinflammatoryfateofth17cells AT ramezwahib inductionandfunctionoftheantiinflammatoryfateofth17cells AT mariacarolinaamezcuavesely inductionandfunctionoftheantiinflammatoryfateofth17cells AT piotrbielecki inductionandfunctionoftheantiinflammatoryfateofth17cells AT willbailis inductionandfunctionoftheantiinflammatoryfateofth17cells AT ruaidhrijackson inductionandfunctionoftheantiinflammatoryfateofth17cells AT danielperez inductionandfunctionoftheantiinflammatoryfateofth17cells AT jakobizbicki inductionandfunctionoftheantiinflammatoryfateofth17cells AT paulaliconalimon inductionandfunctionoftheantiinflammatoryfateofth17cells AT vesakaartinen inductionandfunctionoftheantiinflammatoryfateofth17cells AT jensgeginat inductionandfunctionoftheantiinflammatoryfateofth17cells AT enricesplugues inductionandfunctionoftheantiinflammatoryfateofth17cells AT evatolosa inductionandfunctionoftheantiinflammatoryfateofth17cells AT samuelhuber inductionandfunctionoftheantiinflammatoryfateofth17cells AT richardaflavell inductionandfunctionoftheantiinflammatoryfateofth17cells AT nicolagagliani inductionandfunctionoftheantiinflammatoryfateofth17cells |
| _version_ |
1721320031906693120 |