DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods

DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods

<b>: </b>Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterizat...

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Bibliographic Details
Main Authors: Anna Nastruzzi, Gabriele Pitingolo, Giovanni Luca, Claudio Nastruzzi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Micromachines
Subjects:
hydrogel microbeads
millifluidic devices
cell encapsulation
design of experiments
process optimization
Online Access:https://www.mdpi.com/2072-666X/11/11/1007
Description
Summary:<b>: </b>Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterization of highly controlled and reproducible microbeads made by different types of hydrogel using millifluidic approaches. The optimization of the process was made by a design of experiments (DoE) approach. The microbeads’ large-scale production can be potentially used for single cells or clusters encapsulation.
ISSN:2072-666X

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