DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods

DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods

<b>: </b>Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterizat...

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Main Authors: Anna Nastruzzi, Gabriele Pitingolo, Giovanni Luca, Claudio Nastruzzi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Micromachines
Subjects:
hydrogel microbeads
millifluidic devices
cell encapsulation
design of experiments
process optimization
Online Access:https://www.mdpi.com/2072-666X/11/11/1007
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spelling doaj-fd3e8d64575d4f9fac356a268db946a32020-11-25T04:08:24ZengMDPI AGMicromachines2072-666X2020-11-01111007100710.3390/mi11111007DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic MethodsAnna Nastruzzi0Gabriele Pitingolo1Giovanni Luca2Claudio Nastruzzi3Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44100 Ferrara, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, 44100 Ferrara, ItalyDepartment of Experimental Medicine, University of Perugia, 06123 Perugia, ItalyDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, 44100 Ferrara, Italy<b>: </b>Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterization of highly controlled and reproducible microbeads made by different types of hydrogel using millifluidic approaches. The optimization of the process was made by a design of experiments (DoE) approach. The microbeads’ large-scale production can be potentially used for single cells or clusters encapsulation.https://www.mdpi.com/2072-666X/11/11/1007hydrogel microbeadsmillifluidic devicescell encapsulationdesign of experimentsprocess optimization
collection DOAJ
language English
format Article
sources DOAJ
author Anna Nastruzzi
Gabriele Pitingolo
Giovanni Luca
Claudio Nastruzzi
spellingShingle Anna Nastruzzi
Gabriele Pitingolo
Giovanni Luca
Claudio Nastruzzi
DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods
Micromachines
hydrogel microbeads
millifluidic devices
cell encapsulation
design of experiments
process optimization
author_facet Anna Nastruzzi
Gabriele Pitingolo
Giovanni Luca
Claudio Nastruzzi
author_sort Anna Nastruzzi
title DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods
title_short DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods
title_full DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods
title_fullStr DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods
title_full_unstemmed DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods
title_sort doe analysis of approaches for hydrogel microbeads’ preparation by millifluidic methods
publisher MDPI AG
series Micromachines
issn 2072-666X
publishDate 2020-11-01
description <b>: </b>Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterization of highly controlled and reproducible microbeads made by different types of hydrogel using millifluidic approaches. The optimization of the process was made by a design of experiments (DoE) approach. The microbeads’ large-scale production can be potentially used for single cells or clusters encapsulation.
topic hydrogel microbeads
millifluidic devices
cell encapsulation
design of experiments
process optimization
url https://www.mdpi.com/2072-666X/11/11/1007
work_keys_str_mv AT annanastruzzi doeanalysisofapproachesforhydrogelmicrobeadspreparationbymillifluidicmethods
AT gabrielepitingolo doeanalysisofapproachesforhydrogelmicrobeadspreparationbymillifluidicmethods
AT giovanniluca doeanalysisofapproachesforhydrogelmicrobeadspreparationbymillifluidicmethods
AT claudionastruzzi doeanalysisofapproachesforhydrogelmicrobeadspreparationbymillifluidicmethods
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