neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications
To evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current b...
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Online Access: | https://ieeexplore.ieee.org/document/7155464/ |
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doaj-fd3ef28fe867475cab8ab8a06354eb442021-03-29T18:38:43ZengIEEEIEEE Journal of Translational Engineering in Health and Medicine2168-23722015-01-01311110.1109/JTEHM.2015.24555077155464neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other ApplicationsKyle D. Slater0Nicholas C. Sinclair1Timothy S. Nelson2Peter J. Blamey3Hugh J. Mcdermott4 Bionics Institute, East Melbourne, VIC, Australia Bionics Institute, East Melbourne, VIC, Australia Bionics Institute, East Melbourne, VIC, Australia Bionics Institute, East Melbourne, VIC, Australia Bionics Institute, East Melbourne, VIC, AustraliaTo evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current biphasic pulses, with widely adjustable parameters, to arbitrary configurations of output electrodes. This system is shown to be effective in eliciting visual percepts in a patient with approximately 20 years of light perception vision only due to retinitis pigmentosa, using an electrode array implanted in the suprachoroidal space of the eye. The flexibility of the system also makes it suitable for use in a number of other emerging clinical neurostimulation applications, including epileptic seizure suppression and closed-loop deep brain stimulation. Clinical trial registration number NCT01603576 (www.clinicaltrials.gov).https://ieeexplore.ieee.org/document/7155464/Neurostimulatorelectrical stimulationneural prosthesisvisual prosthesiscortical stimulationdeep brain stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyle D. Slater Nicholas C. Sinclair Timothy S. Nelson Peter J. Blamey Hugh J. Mcdermott |
spellingShingle |
Kyle D. Slater Nicholas C. Sinclair Timothy S. Nelson Peter J. Blamey Hugh J. Mcdermott neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications IEEE Journal of Translational Engineering in Health and Medicine Neurostimulator electrical stimulation neural prosthesis visual prosthesis cortical stimulation deep brain stimulation |
author_facet |
Kyle D. Slater Nicholas C. Sinclair Timothy S. Nelson Peter J. Blamey Hugh J. Mcdermott |
author_sort |
Kyle D. Slater |
title |
neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications |
title_short |
neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications |
title_full |
neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications |
title_fullStr |
neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications |
title_full_unstemmed |
neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications |
title_sort |
neurobi: a highly configurable neurostimulator for a retinal prosthesis and other applications |
publisher |
IEEE |
series |
IEEE Journal of Translational Engineering in Health and Medicine |
issn |
2168-2372 |
publishDate |
2015-01-01 |
description |
To evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current biphasic pulses, with widely adjustable parameters, to arbitrary configurations of output electrodes. This system is shown to be effective in eliciting visual percepts in a patient with approximately 20 years of light perception vision only due to retinitis pigmentosa, using an electrode array implanted in the suprachoroidal space of the eye. The flexibility of the system also makes it suitable for use in a number of other emerging clinical neurostimulation applications, including epileptic seizure suppression and closed-loop deep brain stimulation. Clinical trial registration number NCT01603576 (www.clinicaltrials.gov). |
topic |
Neurostimulator electrical stimulation neural prosthesis visual prosthesis cortical stimulation deep brain stimulation |
url |
https://ieeexplore.ieee.org/document/7155464/ |
work_keys_str_mv |
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