Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure

Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure

The envelope of Human Immunodeficiency Virus type 1 (HIV-1) consists of a liquid-ordered membrane enriched in raft lipids and containing the viral glycoproteins. Previous studies demonstrated that changes in viral membrane lipid composition affecting membrane structure or curvature can impair infect...

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Bibliographic Details
Main Authors: Jon Ander Nieto-Garai, Bärbel Glass, Carmen Bunn, Matthias Giese, Gary Jennings, Beate Brankatschk, Sameer Agarwal, Kathleen Börner, F. Xabier Contreras, Hans-Joachim Knölker, Claudia Zankl, Kai Simons, Cornelia Schroeder, Maier Lorizate, Hans-Georg Kräusslich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
lipidomimetics
HIV-1 envelope
lipid raft modulation
laurdan
membrane order
HIV fusion inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01983/full

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