Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review
Abstract Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), ischemic stroke, and brain tumors, which have...
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doaj-fd4d973b455b45a7914f50a7256260372021-08-29T11:31:34ZengBMCJournal of Nanobiotechnology1477-31552021-08-0119112210.1186/s12951-021-01002-3Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a reviewYing Zhang0Pan Guo1Zhe Ma2Peng Lu3Dereje Kebebe4Zhidong Liu5State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese MedicineAbstract Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), ischemic stroke, and brain tumors, which have severely damaged the quality of life and greatly increased the economic and social burdens. Moreover, partial small molecule drugs and almost all large molecule drugs (such as recombinant protein, therapeutic antibody, and nucleic acid) cannot cross the blood–brain barrier. Therefore, it is especially important to develop a drug delivery system that can effectively deliver therapeutic drugs to the central nervous system for the treatment of central nervous system diseases. Cell penetrating peptides (CPPs) provide a potential strategy for the transport of macromolecules through the blood–brain barrier. This study analyzed and summarized the progress of CPPs in CNS diseases from three aspects: CPPs, the conjugates of CPPs and drug, and CPPs modified nanoparticles to provide scientific basis for the application of CPPs for CNS diseases.https://doi.org/10.1186/s12951-021-01002-3Cell penetrating peptidesCentral nervous system diseasesNanomedicineDrug delivery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Zhang Pan Guo Zhe Ma Peng Lu Dereje Kebebe Zhidong Liu |
spellingShingle |
Ying Zhang Pan Guo Zhe Ma Peng Lu Dereje Kebebe Zhidong Liu Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review Journal of Nanobiotechnology Cell penetrating peptides Central nervous system diseases Nanomedicine Drug delivery |
author_facet |
Ying Zhang Pan Guo Zhe Ma Peng Lu Dereje Kebebe Zhidong Liu |
author_sort |
Ying Zhang |
title |
Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review |
title_short |
Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review |
title_full |
Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review |
title_fullStr |
Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review |
title_full_unstemmed |
Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review |
title_sort |
combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review |
publisher |
BMC |
series |
Journal of Nanobiotechnology |
issn |
1477-3155 |
publishDate |
2021-08-01 |
description |
Abstract Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), ischemic stroke, and brain tumors, which have severely damaged the quality of life and greatly increased the economic and social burdens. Moreover, partial small molecule drugs and almost all large molecule drugs (such as recombinant protein, therapeutic antibody, and nucleic acid) cannot cross the blood–brain barrier. Therefore, it is especially important to develop a drug delivery system that can effectively deliver therapeutic drugs to the central nervous system for the treatment of central nervous system diseases. Cell penetrating peptides (CPPs) provide a potential strategy for the transport of macromolecules through the blood–brain barrier. This study analyzed and summarized the progress of CPPs in CNS diseases from three aspects: CPPs, the conjugates of CPPs and drug, and CPPs modified nanoparticles to provide scientific basis for the application of CPPs for CNS diseases. |
topic |
Cell penetrating peptides Central nervous system diseases Nanomedicine Drug delivery |
url |
https://doi.org/10.1186/s12951-021-01002-3 |
work_keys_str_mv |
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