Axonal remodeling of the corticospinal tract during neurological recovery after stroke
Stroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descending motor pathway, the corticospinal tract (CST) i...
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Wolters Kluwer Medknow Publications
2021-01-01
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doaj-fd4dde06652e418d91f04af3ee90567b2020-12-02T13:12:22ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-0116593994310.4103/1673-5374.297060Axonal remodeling of the corticospinal tract during neurological recovery after strokeZhongwu LiuHongqi XinMichael ChoppStroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descending motor pathway, the corticospinal tract (CST) is the primary pathway to innervate spinal motor neurons, and thus, forms the neuroanatomical basis to control the peripheral muscles for voluntary movements. Here, we review evidence from both experimental animals and stroke patients, regarding CST axonal damage, functional contribution of CST axonal integrity and remodeling to neurological recovery, and therapeutic approaches aimed to enhance CST axonal remodeling after stroke. The new insights gleaned from preclinical and clinical studies may encourage the development of more rational therapeutics with a strategy targeted to promote axonal rewiring for corticospinal innervation, which will significantly impact the current clinical needs of subacute and chronic stroke treatment.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=5;spage=939;epage=943;aulast=Liuaxonal degeneration; axonal integrity; axonal remodeling; corticospinal tract; motor performance; neurological recovery; stroke; therapeutic strategy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhongwu Liu Hongqi Xin Michael Chopp |
spellingShingle |
Zhongwu Liu Hongqi Xin Michael Chopp Axonal remodeling of the corticospinal tract during neurological recovery after stroke Neural Regeneration Research axonal degeneration; axonal integrity; axonal remodeling; corticospinal tract; motor performance; neurological recovery; stroke; therapeutic strategy |
author_facet |
Zhongwu Liu Hongqi Xin Michael Chopp |
author_sort |
Zhongwu Liu |
title |
Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_short |
Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_full |
Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_fullStr |
Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_full_unstemmed |
Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_sort |
axonal remodeling of the corticospinal tract during neurological recovery after stroke |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2021-01-01 |
description |
Stroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descending motor pathway, the corticospinal tract (CST) is the primary pathway to innervate spinal motor neurons, and thus, forms the neuroanatomical basis to control the peripheral muscles for voluntary movements. Here, we review evidence from both experimental animals and stroke patients, regarding CST axonal damage, functional contribution of CST axonal integrity and remodeling to neurological recovery, and therapeutic approaches aimed to enhance CST axonal remodeling after stroke. The new insights gleaned from preclinical and clinical studies may encourage the development of more rational therapeutics with a strategy targeted to promote axonal rewiring for corticospinal innervation, which will significantly impact the current clinical needs of subacute and chronic stroke treatment. |
topic |
axonal degeneration; axonal integrity; axonal remodeling; corticospinal tract; motor performance; neurological recovery; stroke; therapeutic strategy |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=5;spage=939;epage=943;aulast=Liu |
work_keys_str_mv |
AT zhongwuliu axonalremodelingofthecorticospinaltractduringneurologicalrecoveryafterstroke AT hongqixin axonalremodelingofthecorticospinaltractduringneurologicalrecoveryafterstroke AT michaelchopp axonalremodelingofthecorticospinaltractduringneurologicalrecoveryafterstroke |
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1724406376365555712 |