The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We he...
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MDPI AG
2016-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | http://www.mdpi.com/2077-0383/5/3/31 |
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doaj-fd4e48a43d224b7d97f7efd6ada65a532020-11-24T20:51:56ZengMDPI AGJournal of Clinical Medicine2077-03832016-03-01533110.3390/jcm5030031jcm5030031The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A ReviewJessica N. Cooke Bailey0Joshua D. Hoffman1Rebecca J. Sardell2William K. Scott3Margaret A. Pericak-Vance4Jonathan L. Haines5Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USADepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USAJohn P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USAJohn P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USAJohn P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USADepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USAAge-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.http://www.mdpi.com/2077-0383/5/3/31age-related macular degeneration (AMD)geneticsrisk score |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jessica N. Cooke Bailey Joshua D. Hoffman Rebecca J. Sardell William K. Scott Margaret A. Pericak-Vance Jonathan L. Haines |
| spellingShingle |
Jessica N. Cooke Bailey Joshua D. Hoffman Rebecca J. Sardell William K. Scott Margaret A. Pericak-Vance Jonathan L. Haines The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review Journal of Clinical Medicine age-related macular degeneration (AMD) genetics risk score |
| author_facet |
Jessica N. Cooke Bailey Joshua D. Hoffman Rebecca J. Sardell William K. Scott Margaret A. Pericak-Vance Jonathan L. Haines |
| author_sort |
Jessica N. Cooke Bailey |
| title |
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review |
| title_short |
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review |
| title_full |
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review |
| title_fullStr |
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review |
| title_full_unstemmed |
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review |
| title_sort |
application of genetic risk scores in age-related macular degeneration: a review |
| publisher |
MDPI AG |
| series |
Journal of Clinical Medicine |
| issn |
2077-0383 |
| publishDate |
2016-03-01 |
| description |
Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD. |
| topic |
age-related macular degeneration (AMD) genetics risk score |
| url |
http://www.mdpi.com/2077-0383/5/3/31 |
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