CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons
The p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) has been identified as the most prevalent genetic cause of familial and sporadic Parkinson's disease (PD). The Cre-LoxP recombination system has been used to correct the LRRK2-G2019S mutation in patient derived human induced plur...
Main Authors: | Xiaobing Qing, Jonas Walter, Javier Jarazo, Jonathan Arias-Fuenzalida, Anna-Lena Hillje, Jens C. Schwamborn |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-10-01
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Series: | Stem Cell Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S187350611730168X |
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