Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause...
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doaj-fd5d28c073c14795a2143d94bb36c05a2020-11-24T22:57:41ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942018-01-01201810.1155/2018/15018471501847Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research TrendsGrazia Tamma0Giovanna Valenti1Elena Grossini2Sandra Donnini3Angela Marino4Raul A. Marinelli5Giuseppe Calamita6Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, ItalyDepartment of Translational Medicine, University of Eastern Piedmont, Novara, ItalyDepartment of Life Sciences, University of Siena, Siena, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, ItalyInstituto de Fisiología Experimental, CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, ArgentinaDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, ItalyReactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.http://dx.doi.org/10.1155/2018/1501847 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grazia Tamma Giovanna Valenti Elena Grossini Sandra Donnini Angela Marino Raul A. Marinelli Giuseppe Calamita |
spellingShingle |
Grazia Tamma Giovanna Valenti Elena Grossini Sandra Donnini Angela Marino Raul A. Marinelli Giuseppe Calamita Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends Oxidative Medicine and Cellular Longevity |
author_facet |
Grazia Tamma Giovanna Valenti Elena Grossini Sandra Donnini Angela Marino Raul A. Marinelli Giuseppe Calamita |
author_sort |
Grazia Tamma |
title |
Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends |
title_short |
Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends |
title_full |
Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends |
title_fullStr |
Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends |
title_full_unstemmed |
Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends |
title_sort |
aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2018-01-01 |
description |
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed. |
url |
http://dx.doi.org/10.1155/2018/1501847 |
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