Biomarkers of brain plasticity in multiple sclerosis
Neuroplasticity is the ability of the brain to adjust to internal and external environmental changes that physiologically take place during the entire life. Particularly interesting is the response of the brain to damage in patients with multiple sclerosis, which is a chronic disease that leads to i...
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Medical Communications Sp. z o.o.
2019-05-01
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doaj-fd62b1500d134dacbf87736a6b8ad7e42020-11-25T02:31:44ZengMedical Communications Sp. z o.o.Aktualności Neurologiczne1641-92272451-06962019-05-01191131810.15557/AN.2019.0003Biomarkers of brain plasticity in multiple sclerosisMarta Milewska-Jędrzejczak0Agnieszka Damiza-Detmer1Izabela Damiza2Andrzej Głąbiński3 Klinika Neurologii i Udarów Mózgu, Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej w Łodzi, Łódź, Polska Klinika Neurologii i Udarów Mózgu, Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej w Łodzi, Łódź, PolskaCollegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Bydgoszcz, PolskaKlinika Neurologii i Udarów Mózgu, Uniwersytet Medyczny w Łodzi, Łódź, PolskaNeuroplasticity is the ability of the brain to adjust to internal and external environmental changes that physiologically take place during the entire life. Particularly interesting is the response of the brain to damage in patients with multiple sclerosis, which is a chronic disease that leads to inflammatory and neurodegenerative central nervous system damage. While in healthy individuals brain plasticity is based on brain development, learning processes and memory, in multiple sclerosis it involves changes at the molecular, synaptic and cellular level as well as reorganisation of the cortex and brain fibres, leading to the restoration of functions which were lost in the course of acute or chronic damaging processes. Functional magnetic resonance imaging helps examine functional changes associated with the disease and its evolution. Several studies have shown that abnormal brain activation during certain tasks is seen in early stages of the disease. Enhanced functional activation of the brain has been interpreted as adaptation neuroplasticity to counteract the accumulation of tissue damage. The article presents the principles of functional magnetic resonance imaging which plays a significant role in demonstrating neural plasticity. Moreover, the authors discuss molecular factors that are probably responsible for neuroplasticity.http://www.neurologia.com.pl/index.php/issues/2019-vol-19-no-1/biomarkers-of-brain-plasticity-in-multiple-sclerosis?aid=1032brain plasticityneuroplasticitymultiple sclerosisfunctional magnetic resonance imagingfmrineurorehabilitation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Milewska-Jędrzejczak Agnieszka Damiza-Detmer Izabela Damiza Andrzej Głąbiński |
spellingShingle |
Marta Milewska-Jędrzejczak Agnieszka Damiza-Detmer Izabela Damiza Andrzej Głąbiński Biomarkers of brain plasticity in multiple sclerosis Aktualności Neurologiczne brain plasticity neuroplasticity multiple sclerosis functional magnetic resonance imaging fmri neurorehabilitation |
author_facet |
Marta Milewska-Jędrzejczak Agnieszka Damiza-Detmer Izabela Damiza Andrzej Głąbiński |
author_sort |
Marta Milewska-Jędrzejczak |
title |
Biomarkers of brain plasticity in multiple sclerosis |
title_short |
Biomarkers of brain plasticity in multiple sclerosis |
title_full |
Biomarkers of brain plasticity in multiple sclerosis |
title_fullStr |
Biomarkers of brain plasticity in multiple sclerosis |
title_full_unstemmed |
Biomarkers of brain plasticity in multiple sclerosis |
title_sort |
biomarkers of brain plasticity in multiple sclerosis |
publisher |
Medical Communications Sp. z o.o. |
series |
Aktualności Neurologiczne |
issn |
1641-9227 2451-0696 |
publishDate |
2019-05-01 |
description |
Neuroplasticity is the ability of the brain to adjust to internal and external environmental changes that physiologically take place during the entire life. Particularly interesting is the response of the brain to damage in patients with multiple sclerosis, which is a chronic disease that leads to inflammatory and neurodegenerative central nervous system damage. While in healthy individuals brain plasticity is based on brain development, learning processes and memory, in multiple sclerosis it involves changes at the molecular, synaptic and cellular level as well as reorganisation of the cortex and brain fibres, leading to the restoration of functions which were lost in the course of acute or chronic damaging processes. Functional magnetic resonance imaging helps examine functional changes associated with the disease and its evolution. Several studies have shown that abnormal brain activation during certain tasks is seen in early stages of the disease. Enhanced functional activation of the brain has been interpreted as adaptation neuroplasticity to counteract the accumulation of tissue damage. The article presents the principles of functional magnetic resonance imaging which plays a significant role in demonstrating neural plasticity. Moreover, the authors discuss molecular factors that are probably responsible for neuroplasticity. |
topic |
brain plasticity neuroplasticity multiple sclerosis functional magnetic resonance imaging fmri neurorehabilitation |
url |
http://www.neurologia.com.pl/index.php/issues/2019-vol-19-no-1/biomarkers-of-brain-plasticity-in-multiple-sclerosis?aid=1032 |
work_keys_str_mv |
AT martamilewskajedrzejczak biomarkersofbrainplasticityinmultiplesclerosis AT agnieszkadamizadetmer biomarkersofbrainplasticityinmultiplesclerosis AT izabeladamiza biomarkersofbrainplasticityinmultiplesclerosis AT andrzejgłabinski biomarkersofbrainplasticityinmultiplesclerosis |
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