HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.
HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n ...
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doaj-fd6c9c8dd0d242fc880a781ea4fff4132021-03-04T01:03:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0172e3186510.1371/journal.pone.0031865HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.Xin HuangBouke HepkemaIlja NolteKushi KushekharTheo JongsmaRianne VeenstraSibrand PoppemaZifen GaoLydia VisserArjan DiepstraAnke van den BergHLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV- cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A*02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV- cHL and 20% in controls. Significant differences were also observed for the HLA-A*02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2×10(-5)). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cHL in the northern Chinese population.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22355400/pdf/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Huang Bouke Hepkema Ilja Nolte Kushi Kushekhar Theo Jongsma Rianne Veenstra Sibrand Poppema Zifen Gao Lydia Visser Arjan Diepstra Anke van den Berg |
spellingShingle |
Xin Huang Bouke Hepkema Ilja Nolte Kushi Kushekhar Theo Jongsma Rianne Veenstra Sibrand Poppema Zifen Gao Lydia Visser Arjan Diepstra Anke van den Berg HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China. PLoS ONE |
author_facet |
Xin Huang Bouke Hepkema Ilja Nolte Kushi Kushekhar Theo Jongsma Rianne Veenstra Sibrand Poppema Zifen Gao Lydia Visser Arjan Diepstra Anke van den Berg |
author_sort |
Xin Huang |
title |
HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China. |
title_short |
HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China. |
title_full |
HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China. |
title_fullStr |
HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China. |
title_full_unstemmed |
HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China. |
title_sort |
hla-a*02:07 is a protective allele for ebv negative and a susceptibility allele for ebv positive classical hodgkin lymphoma in china. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV- cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A*02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV- cHL and 20% in controls. Significant differences were also observed for the HLA-A*02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2×10(-5)). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cHL in the northern Chinese population. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22355400/pdf/?tool=EBI |
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