Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy

Today, cancer is one of the most common causes of death. Osteosarcoma (OS) is a tumor in long bones and its prevalence is high in teenagers and young people. Among the methods that used to treat cancer, one can name chemotherapy, surgery, and radiotherapy. Since these methods have some disadvantages...

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Main Authors:	Sama Izadpanah, Parastoo Shabani, Ali Aghebati-Maleki, Elham Baghbani, Amir Baghbanzadeh, Ali Fotouhi, Babak Bakhshinejad, Leili Aghebati-Maleki, Behzad Baradaran
Format:	Article
Language:	English
Published:	Elsevier 2019-03-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Cancer microRNA miR-193 Osteosarcoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332218354143

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spelling	doaj-fd6cbd291a7c4e708ade6a91d840e08d2021-05-20T07:35:41ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-03-01111873881Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapySama Izadpanah0Parastoo Shabani1Ali Aghebati-Maleki2Elham Baghbani3Amir Baghbanzadeh4Ali Fotouhi5Babak Bakhshinejad6Leili Aghebati-Maleki7Behzad Baradaran8Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Orthopedic Surgery, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranOkinawa Institute of Science and Technology Graduate University, Okinawa, JapanImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding authors at: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding authors at: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Today, cancer is one of the most common causes of death. Osteosarcoma (OS) is a tumor in long bones and its prevalence is high in teenagers and young people. Among the methods that used to treat cancer, one can name chemotherapy, surgery, and radiotherapy. Since these methods have some disadvantages and they are not absolutely successful, the use of microRNAs (miRNAs) is very useful in diagnosis and treatment of OS. MiRNAs are small non-coding RNA molecules, containing 18–25 nucleotides, which are involved in the regulation of gene expression via binding to messenger RNA (mRNA). These RNAs are divided into two classes of suppressors and oncogenes. During OS, there is aberrant expression of several miRNAs. Among these miRNAs are downregulation of miR-193 that has been associated with cancer occurrence. The aim of the current manuscript is to have overview on the treatment approaches of OS with special focus on miR-193.http://www.sciencedirect.com/science/article/pii/S0753332218354143CancermicroRNAmiR-193Osteosarcoma
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sama Izadpanah Parastoo Shabani Ali Aghebati-Maleki Elham Baghbani Amir Baghbanzadeh Ali Fotouhi Babak Bakhshinejad Leili Aghebati-Maleki Behzad Baradaran
spellingShingle	Sama Izadpanah Parastoo Shabani Ali Aghebati-Maleki Elham Baghbani Amir Baghbanzadeh Ali Fotouhi Babak Bakhshinejad Leili Aghebati-Maleki Behzad Baradaran Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy Biomedicine & Pharmacotherapy Cancer microRNA miR-193 Osteosarcoma
author_facet	Sama Izadpanah Parastoo Shabani Ali Aghebati-Maleki Elham Baghbani Amir Baghbanzadeh Ali Fotouhi Babak Bakhshinejad Leili Aghebati-Maleki Behzad Baradaran
author_sort	Sama Izadpanah
title	Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy
title_short	Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy
title_full	Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy
title_fullStr	Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy
title_full_unstemmed	Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy
title_sort	insights into the roles of mirnas; mir-193 as one of small molecular silencer in osteosarcoma therapy
publisher	Elsevier
series	Biomedicine & Pharmacotherapy
issn	0753-3322
publishDate	2019-03-01
description	Today, cancer is one of the most common causes of death. Osteosarcoma (OS) is a tumor in long bones and its prevalence is high in teenagers and young people. Among the methods that used to treat cancer, one can name chemotherapy, surgery, and radiotherapy. Since these methods have some disadvantages and they are not absolutely successful, the use of microRNAs (miRNAs) is very useful in diagnosis and treatment of OS. MiRNAs are small non-coding RNA molecules, containing 18–25 nucleotides, which are involved in the regulation of gene expression via binding to messenger RNA (mRNA). These RNAs are divided into two classes of suppressors and oncogenes. During OS, there is aberrant expression of several miRNAs. Among these miRNAs are downregulation of miR-193 that has been associated with cancer occurrence. The aim of the current manuscript is to have overview on the treatment approaches of OS with special focus on miR-193.
topic	Cancer microRNA miR-193 Osteosarcoma
url	http://www.sciencedirect.com/science/article/pii/S0753332218354143
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Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy

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