Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives

Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives

Vitamin E is easily oxidized by light, air, oxidizing agents and heat, limiting its application in many ways. Compared to vitamin E, vitamin E ester derivatives exhibit improved stability and a stronger antioxidant capacity, and even gain new biological functions. In recent years, enzymatic synthesi...

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Main Authors: Zhiqiang Zou, Lingmei Dai, Dehua Liu, Wei Du
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Catalysts
Subjects:
antioxidants
derivatives
lipase
vitamin E
vitamin E ester
Online Access:https://www.mdpi.com/2073-4344/11/6/739
id doaj-fd72b68fde8a41dc8fc3658ee0a40c27
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spelling doaj-fd72b68fde8a41dc8fc3658ee0a40c272021-07-01T00:21:57ZengMDPI AGCatalysts2073-43442021-06-011173973910.3390/catal11060739Research Progress in Enzymatic Synthesis of Vitamin E Ester DerivativesZhiqiang Zou0Lingmei Dai1Dehua Liu2Wei Du3Key Laboratory for Industrial Biocatalysis, Department of Chemical Engineering, Tsinghua University, Ministry of Education, Beijing 100084, ChinaKey Laboratory for Industrial Biocatalysis, Department of Chemical Engineering, Tsinghua University, Ministry of Education, Beijing 100084, ChinaKey Laboratory for Industrial Biocatalysis, Department of Chemical Engineering, Tsinghua University, Ministry of Education, Beijing 100084, ChinaKey Laboratory for Industrial Biocatalysis, Department of Chemical Engineering, Tsinghua University, Ministry of Education, Beijing 100084, ChinaVitamin E is easily oxidized by light, air, oxidizing agents and heat, limiting its application in many ways. Compared to vitamin E, vitamin E ester derivatives exhibit improved stability and a stronger antioxidant capacity, and even gain new biological functions. In recent years, enzymatic synthesis of vitamin E ester derivatives has received increasing attention due to its environmental friendliness, high catalytic efficiency, and inherent selectivity. This paper reviews the related progress of lipase-mediated preparation of vitamin E ester derivatives. The function of different vitamin E ester derivatives, and the main factors influencing the enzymatic acylation process, including enzyme species, acyl donor and acceptor, reaction media and water activity, are summarized in this paper. Finally, the perspective of lipase-catalyzed synthesis of vitamin E ester derivatives is also discussed.https://www.mdpi.com/2073-4344/11/6/739antioxidantsderivativeslipasevitamin Evitamin E ester
collection DOAJ
language English
format Article
sources DOAJ
author Zhiqiang Zou
Lingmei Dai
Dehua Liu
Wei Du
spellingShingle Zhiqiang Zou
Lingmei Dai
Dehua Liu
Wei Du
Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives
Catalysts
antioxidants
derivatives
lipase
vitamin E
vitamin E ester
author_facet Zhiqiang Zou
Lingmei Dai
Dehua Liu
Wei Du
author_sort Zhiqiang Zou
title Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives
title_short Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives
title_full Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives
title_fullStr Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives
title_full_unstemmed Research Progress in Enzymatic Synthesis of Vitamin E Ester Derivatives
title_sort research progress in enzymatic synthesis of vitamin e ester derivatives
publisher MDPI AG
series Catalysts
issn 2073-4344
publishDate 2021-06-01
description Vitamin E is easily oxidized by light, air, oxidizing agents and heat, limiting its application in many ways. Compared to vitamin E, vitamin E ester derivatives exhibit improved stability and a stronger antioxidant capacity, and even gain new biological functions. In recent years, enzymatic synthesis of vitamin E ester derivatives has received increasing attention due to its environmental friendliness, high catalytic efficiency, and inherent selectivity. This paper reviews the related progress of lipase-mediated preparation of vitamin E ester derivatives. The function of different vitamin E ester derivatives, and the main factors influencing the enzymatic acylation process, including enzyme species, acyl donor and acceptor, reaction media and water activity, are summarized in this paper. Finally, the perspective of lipase-catalyzed synthesis of vitamin E ester derivatives is also discussed.
topic antioxidants
derivatives
lipase
vitamin E
vitamin E ester
url https://www.mdpi.com/2073-4344/11/6/739
work_keys_str_mv AT zhiqiangzou researchprogressinenzymaticsynthesisofvitamineesterderivatives
AT lingmeidai researchprogressinenzymaticsynthesisofvitamineesterderivatives
AT dehualiu researchprogressinenzymaticsynthesisofvitamineesterderivatives
AT weidu researchprogressinenzymaticsynthesisofvitamineesterderivatives
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