Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient...
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2011-01-01
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doaj-fd77c62af167475ab91003b595e709312020-11-25T00:23:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0165e2055910.1371/journal.pone.0020559Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.Kush N PatelQin LiuSonya MeekerBradley J UndemXinzhong DongItch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt(-/-) mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways.http://europepmc.org/articles/PMC3105090?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kush N Patel Qin Liu Sonya Meeker Bradley J Undem Xinzhong Dong |
spellingShingle |
Kush N Patel Qin Liu Sonya Meeker Bradley J Undem Xinzhong Dong Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. PLoS ONE |
author_facet |
Kush N Patel Qin Liu Sonya Meeker Bradley J Undem Xinzhong Dong |
author_sort |
Kush N Patel |
title |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. |
title_short |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. |
title_full |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. |
title_fullStr |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. |
title_full_unstemmed |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. |
title_sort |
pirt, a trpv1 modulator, is required for histamine-dependent and -independent itch. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt(-/-) mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways. |
url |
http://europepmc.org/articles/PMC3105090?pdf=render |
work_keys_str_mv |
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