Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14335 |
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doaj-fd8251bd4bfc4bada3441c9bdef9e02e2021-05-11T07:19:29ZengNature Publishing GroupNature Communications2041-17232017-02-018111710.1038/ncomms14335Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 couplingChun-Hua Liu0Zheng Gong1Zong-Lai Liang2Zhi-Xin Liu3Fan Yang4Yu-Jing Sun5Ming-Liang Ma6Yi-Jing Wang7Chao-Ran Ji8Yu-Hong Wang9Mei-Jie Wang10Fu-Ai Cui11Amy Lin12Wen-Shuai Zheng13Dong-Fang He14Chang-xiu Qu15Peng Xiao16Chuan-Yong Liu17Alex R. B. Thomsen18Thomas Joseph Cahill19Alem W. Kahsai20Fan Yi21Kun-Hong Xiao22Tian Xue23Zhuan Zhou24Xiao Yu25Jin-Peng Sun26Department of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Physiology, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Physiology, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Physiology, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDuke University, School of MedicineDepartment of Physiology, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineDepartment of Physiology, Shandong University School of MedicineDuke University, School of MedicineDuke University, School of MedicineDuke University, School of MedicineDepartment of Pharmacology, Shandong University School of MedicineDuke University, School of MedicineHefei National Laboratory for Physical Science at Microscale, School of Life Science, University of Science and Technology of ChinaLaboratory of Cellular Biophysics and Neurodegeneration, Ying-Jie Conference Center, Peking UniversityDepartment of Physiology, Shandong University School of MedicineDepartment of Biochemistry and Molecular Biology, Key Laboratory Experimental Teratology of the Ministry of Education, Shandong University School of MedicineAngiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion.https://doi.org/10.1038/ncomms14335 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chun-Hua Liu Zheng Gong Zong-Lai Liang Zhi-Xin Liu Fan Yang Yu-Jing Sun Ming-Liang Ma Yi-Jing Wang Chao-Ran Ji Yu-Hong Wang Mei-Jie Wang Fu-Ai Cui Amy Lin Wen-Shuai Zheng Dong-Fang He Chang-xiu Qu Peng Xiao Chuan-Yong Liu Alex R. B. Thomsen Thomas Joseph Cahill Alem W. Kahsai Fan Yi Kun-Hong Xiao Tian Xue Zhuan Zhou Xiao Yu Jin-Peng Sun |
| spellingShingle |
Chun-Hua Liu Zheng Gong Zong-Lai Liang Zhi-Xin Liu Fan Yang Yu-Jing Sun Ming-Liang Ma Yi-Jing Wang Chao-Ran Ji Yu-Hong Wang Mei-Jie Wang Fu-Ai Cui Amy Lin Wen-Shuai Zheng Dong-Fang He Chang-xiu Qu Peng Xiao Chuan-Yong Liu Alex R. B. Thomsen Thomas Joseph Cahill Alem W. Kahsai Fan Yi Kun-Hong Xiao Tian Xue Zhuan Zhou Xiao Yu Jin-Peng Sun Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling Nature Communications |
| author_facet |
Chun-Hua Liu Zheng Gong Zong-Lai Liang Zhi-Xin Liu Fan Yang Yu-Jing Sun Ming-Liang Ma Yi-Jing Wang Chao-Ran Ji Yu-Hong Wang Mei-Jie Wang Fu-Ai Cui Amy Lin Wen-Shuai Zheng Dong-Fang He Chang-xiu Qu Peng Xiao Chuan-Yong Liu Alex R. B. Thomsen Thomas Joseph Cahill Alem W. Kahsai Fan Yi Kun-Hong Xiao Tian Xue Zhuan Zhou Xiao Yu Jin-Peng Sun |
| author_sort |
Chun-Hua Liu |
| title |
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling |
| title_short |
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling |
| title_full |
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling |
| title_fullStr |
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling |
| title_full_unstemmed |
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling |
| title_sort |
arrestin-biased at1r agonism induces acute catecholamine secretion through trpc3 coupling |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-02-01 |
| description |
Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent calcium influx and catecholamine secretion. |
| url |
https://doi.org/10.1038/ncomms14335 |
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