Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis.
BACKGROUND: The insulin-like growth factor (IGF) system was documented to play a predominant role in neoplasia. As lung cancer is one of the most malignant cancers, we conducted a meta-analysis in order to investigate the strength of association between circulating IGF-1 and IGFBP-3 levels and lung...
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doaj-fd8756d4916849238b890c38b76e37802020-11-24T21:53:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4988410.1371/journal.pone.0049884Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis.Hongxin CaoGuanghui WangLong MengHongchang ShenZhen FengQi LiuJiajun DuBACKGROUND: The insulin-like growth factor (IGF) system was documented to play a predominant role in neoplasia. As lung cancer is one of the most malignant cancers, we conducted a meta-analysis in order to investigate the strength of association between circulating IGF-1 and IGFBP-3 levels and lung cancer. METHODOLOGY/PRINCIPAL FINDINGS: A systematic literature search was conducted to identify all prospective case-control studies and case-control studies on circulating IGFs and IGFBPs levels. Six nested case-control studies (1 043 case subjects and 11 472 control participants) and eight case-control studies (401 case subjects and 343 control participants) were included in this meta-analysis. Pooled measure was calculated as the inverse variance-weighted mean of the natural logarithm of multivariate adjusted OR with 95% CIs for highest vs. lowest levels to assess the association of circulating IGF-1 and IGFBP-3 concentrations and lung cancer. Standard mean difference (SMD) was also calculated to indicate the difference of the circulating IGF-1 and IGFBP-3 concentrations between the lung cancer case group and the control group. Of the nested case-control studies, ORs for the highest vs. lowest levels of IGF-1 and IGFBP-3 were 1.047 (95% CI: [0.802,1.367], P = 0.736) and 0.960 (95%CI: [0.591,1.559], P = 0.868) respectively; and SMDs were -0.079 (95%CI:[ -0.169, 0.011], P = 0.086) and -0.097 (95%CI:[ -0.264,0.071], P = 0.258) for IGF-1 and IGFBP-3 respectively. As to the case-control studies, SMDs were 0.568 (95%CI:[ -0.035, 1.171], P = 0.065) and -0.780 (95%CI:[ -1.358, -0.201], P = 0.008) for IGF-1 and IGFBP-3 respectively. CONCLUSIONS/SIGNIFICANCE: Inverse association was shown between IGFBP-3 and lung cancer in the case-control studies,and the circulating level of IGFBP-3 underwent a decline during tumorogenesis and development of lung cancer, which suggested IGFBP-3 a promising candidate for the biomarker of lung cancer.http://europepmc.org/articles/PMC3501472?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongxin Cao Guanghui Wang Long Meng Hongchang Shen Zhen Feng Qi Liu Jiajun Du |
spellingShingle |
Hongxin Cao Guanghui Wang Long Meng Hongchang Shen Zhen Feng Qi Liu Jiajun Du Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. PLoS ONE |
author_facet |
Hongxin Cao Guanghui Wang Long Meng Hongchang Shen Zhen Feng Qi Liu Jiajun Du |
author_sort |
Hongxin Cao |
title |
Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. |
title_short |
Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. |
title_full |
Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. |
title_fullStr |
Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. |
title_full_unstemmed |
Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. |
title_sort |
association between circulating levels of igf-1 and igfbp-3 and lung cancer risk: a meta-analysis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
BACKGROUND: The insulin-like growth factor (IGF) system was documented to play a predominant role in neoplasia. As lung cancer is one of the most malignant cancers, we conducted a meta-analysis in order to investigate the strength of association between circulating IGF-1 and IGFBP-3 levels and lung cancer. METHODOLOGY/PRINCIPAL FINDINGS: A systematic literature search was conducted to identify all prospective case-control studies and case-control studies on circulating IGFs and IGFBPs levels. Six nested case-control studies (1 043 case subjects and 11 472 control participants) and eight case-control studies (401 case subjects and 343 control participants) were included in this meta-analysis. Pooled measure was calculated as the inverse variance-weighted mean of the natural logarithm of multivariate adjusted OR with 95% CIs for highest vs. lowest levels to assess the association of circulating IGF-1 and IGFBP-3 concentrations and lung cancer. Standard mean difference (SMD) was also calculated to indicate the difference of the circulating IGF-1 and IGFBP-3 concentrations between the lung cancer case group and the control group. Of the nested case-control studies, ORs for the highest vs. lowest levels of IGF-1 and IGFBP-3 were 1.047 (95% CI: [0.802,1.367], P = 0.736) and 0.960 (95%CI: [0.591,1.559], P = 0.868) respectively; and SMDs were -0.079 (95%CI:[ -0.169, 0.011], P = 0.086) and -0.097 (95%CI:[ -0.264,0.071], P = 0.258) for IGF-1 and IGFBP-3 respectively. As to the case-control studies, SMDs were 0.568 (95%CI:[ -0.035, 1.171], P = 0.065) and -0.780 (95%CI:[ -1.358, -0.201], P = 0.008) for IGF-1 and IGFBP-3 respectively. CONCLUSIONS/SIGNIFICANCE: Inverse association was shown between IGFBP-3 and lung cancer in the case-control studies,and the circulating level of IGFBP-3 underwent a decline during tumorogenesis and development of lung cancer, which suggested IGFBP-3 a promising candidate for the biomarker of lung cancer. |
url |
http://europepmc.org/articles/PMC3501472?pdf=render |
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