The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study
Objective: To investigate the relationship between insulin resistance and hepcidin levels in patients with PCOS. Materials and methods: In this case–control study fifty- six patients with PCOS and forty – one healthy control subjects were included. Plasma levels of hepcidin, IL-6, Serum Insulin a...
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Tehran University of Medical Sciences
2019-03-01
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doaj-fd89c5e3ec6c43b78283245ce8d7219b2021-04-02T12:46:07ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922019-03-01124971The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control StudyBatool Hossein Rashidi0Soheila Shams1Mamak Shariat2Maryam Bagheri3Marziyeh Mohebi4Fedyeh Haghollahi5Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, IranVali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, IranMaternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IranVali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, IranVali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Objective: To investigate the relationship between insulin resistance and hepcidin levels in patients with PCOS. Materials and methods: In this case–control study fifty- six patients with PCOS and forty – one healthy control subjects were included. Plasma levels of hepcidin, IL-6, Serum Insulin and ferritin using ELISA method, serum iron levels using a spectrophotometric method, and Insulin resistance by using HOMA were measured in the two groups of PCOS (case group) and healthy subjects (control group). The results were analyzed by student’s t-test, General Linear Model, Binary logistic and linear regression tests. Results: The mean hepcidin level was 1.97 ± 0.53 pg/ml and 2.40 ± 0.25pg/ml in the case and control groups, respectively. The t-test results showed a significant difference between the two groups (p = 0.0001). The mean of insulin level in case and control group was 30.65 ± 15.02g/dl and 14.71 ± 10.46g/dl, respectively. The t-test analysis indicated a significant difference between the two groups (p = 0.0001). There was an inverse relationship between the level of hepcidin with HOMA-IR (β = -0.629, p = 0.04), and IL-6 (β = -0.243, p = 0.015) in both groups. The adjusted OR proved a statistically significant association between serum hepcidin (OR = 0.063; 95 % CI: 0.01-0.385, p-value = 0. 003) and HOMA (OR = 1.569; 95 % CI: 1.254–1.964, p-value = 0.001) with PolycysticOvarian Syndrome. Conclusion: There was an inverse relationship between hepcidin levels and insulin resistance in both groups meaning decrease in hepcidin levels and increase in insulin resistance may increase the risk of PCOS. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/971PCOSHepcidinSerum InsulinInsulin Resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Batool Hossein Rashidi Soheila Shams Mamak Shariat Maryam Bagheri Marziyeh Mohebi Fedyeh Haghollahi |
spellingShingle |
Batool Hossein Rashidi Soheila Shams Mamak Shariat Maryam Bagheri Marziyeh Mohebi Fedyeh Haghollahi The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study Journal of Family and Reproductive Health PCOS Hepcidin Serum Insulin Insulin Resistance |
author_facet |
Batool Hossein Rashidi Soheila Shams Mamak Shariat Maryam Bagheri Marziyeh Mohebi Fedyeh Haghollahi |
author_sort |
Batool Hossein Rashidi |
title |
The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study |
title_short |
The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study |
title_full |
The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study |
title_fullStr |
The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study |
title_full_unstemmed |
The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study |
title_sort |
association of serum hepcidin levels and insulin resistance in pcos patients: a case-control study |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Family and Reproductive Health |
issn |
1735-8949 1735-9392 |
publishDate |
2019-03-01 |
description |
Objective: To investigate the relationship between insulin resistance and hepcidin levels in patients
with PCOS.
Materials and methods: In this case–control study fifty- six patients with PCOS and forty – one healthy control subjects were included. Plasma levels of hepcidin, IL-6, Serum Insulin and ferritin using ELISA method, serum iron levels using a spectrophotometric method, and Insulin resistance by using HOMA were measured in the two groups of PCOS (case group) and healthy subjects (control group). The results were analyzed by student’s t-test, General Linear Model, Binary logistic and linear regression tests.
Results: The mean hepcidin level was 1.97 ± 0.53 pg/ml and 2.40 ± 0.25pg/ml in the case and control groups, respectively. The t-test results showed a significant difference between the two groups
(p = 0.0001). The mean of insulin level in case and control group was 30.65 ± 15.02g/dl and
14.71 ± 10.46g/dl, respectively. The t-test analysis indicated a significant difference between the two groups (p = 0.0001). There was an inverse relationship between the level of hepcidin with HOMA-IR
(β = -0.629, p = 0.04), and IL-6 (β = -0.243, p = 0.015) in both groups. The adjusted OR proved a statistically significant association between serum hepcidin (OR = 0.063; 95 % CI: 0.01-0.385,
p-value = 0. 003) and HOMA (OR = 1.569; 95 % CI: 1.254–1.964, p-value = 0.001) with PolycysticOvarian Syndrome.
Conclusion: There was an inverse relationship between hepcidin levels and insulin resistance in both groups meaning decrease in hepcidin levels and increase in insulin resistance may increase the risk of PCOS.
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topic |
PCOS Hepcidin Serum Insulin Insulin Resistance |
url |
https://jfrh.tums.ac.ir/index.php/jfrh/article/view/971 |
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