Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents
The preparation of monodisperse and biocompatible water-soluble super-paramagnetic iron oxide nanoparticles (SPIONs) with high sensitivity in Magnetic Resonance Imaging (MRI) represents a challenge for the development of contrast agents. Here we report the synthesis of highly monodisperse citric aci...
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Accademia Peloritana dei Pericolanti
2018-11-01
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http://dx.doi.org/10.1478/AAPP.962A5
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doaj-fd8c0b859a994402aa7323d3e116680e2020-11-24T21:47:09ZengAccademia Peloritana dei PericolantiAtti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali0365-03591825-12422018-11-01962A510.1478/AAPP.962A5AAPP.962A5Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agentsErnesto AmatoPaola LanzafameAntonio ItalianoGiuseppe CiceroGeorgia PapanikolaouSiglinda PerathonerGabriele CentiFabio MinutoliThe preparation of monodisperse and biocompatible water-soluble super-paramagnetic iron oxide nanoparticles (SPIONs) with high sensitivity in Magnetic Resonance Imaging (MRI) represents a challenge for the development of contrast agents. Here we report the synthesis of highly monodisperse citric acid (CA) coated SPIONs with an average diameter of 9 nm and spherical shape, prepared through a suitably optimized coprecipitation method. CA-SPIONs show a high solubility and stability in aqueous medium. Imaging of CA-SPIONs aqueous suspensions was performed in a clinical 1.5-T MRI scanner and different clinical acquisition sequences were exploited. Results show that image contrast can be effectively improved when concentrations of SPIONs lower than 1 ppm are present, and that the echo time is the main parameter influencing the image contrast of SPION-loaded solutions. Moreover, we found that CA-SPIONs show a high value of transverse relaxivity of 128 L mmol^(-1) s^(-1) (higher than the commercial contrast agents). Our results are encouraging for the further development of clinical application of SPIONs in MRI, and can represent a starting point for the optimization of clinical imaging exploiting the contrast enhancement of such agents. Namely, it seems possible to achieve an optimal image contrast with low concentration of SPIONs; this could lead to a lower probability of side effects. http://dx.doi.org/10.1478/AAPP.962A5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ernesto Amato Paola Lanzafame Antonio Italiano Giuseppe Cicero Georgia Papanikolaou Siglinda Perathoner Gabriele Centi Fabio Minutoli |
spellingShingle |
Ernesto Amato Paola Lanzafame Antonio Italiano Giuseppe Cicero Georgia Papanikolaou Siglinda Perathoner Gabriele Centi Fabio Minutoli Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali |
author_facet |
Ernesto Amato Paola Lanzafame Antonio Italiano Giuseppe Cicero Georgia Papanikolaou Siglinda Perathoner Gabriele Centi Fabio Minutoli |
author_sort |
Ernesto Amato |
title |
Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents |
title_short |
Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents |
title_full |
Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents |
title_fullStr |
Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents |
title_full_unstemmed |
Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents |
title_sort |
monodisperse magnetite nanoparticles with high sensitivity as mri contrast agents |
publisher |
Accademia Peloritana dei Pericolanti |
series |
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali |
issn |
0365-0359 1825-1242 |
publishDate |
2018-11-01 |
description |
The preparation of monodisperse and biocompatible water-soluble super-paramagnetic iron oxide nanoparticles (SPIONs) with high sensitivity in Magnetic Resonance Imaging (MRI) represents a challenge for the development of contrast agents. Here we report the synthesis of highly monodisperse citric acid (CA) coated SPIONs with an average diameter of 9 nm and spherical shape, prepared through a suitably optimized coprecipitation method. CA-SPIONs show a high solubility and stability in aqueous medium. Imaging of CA-SPIONs aqueous suspensions was performed in a clinical 1.5-T MRI scanner and different clinical acquisition sequences were exploited. Results show that image contrast can be effectively improved when concentrations of SPIONs lower than 1 ppm are present, and that the echo time is the main parameter influencing the image contrast of SPION-loaded solutions. Moreover, we found that CA-SPIONs show a high value of transverse relaxivity of 128 L mmol^(-1) s^(-1) (higher than the commercial contrast agents). Our results are encouraging for the further development of clinical application of SPIONs in MRI, and can represent a starting point for the optimization of clinical imaging exploiting the contrast enhancement of such agents. Namely, it seems possible to achieve an optimal image contrast with low concentration of SPIONs; this could lead to a lower probability of side effects. |
url |
http://dx.doi.org/10.1478/AAPP.962A5
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