Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders
The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its ve...
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Wolters Kluwer Medknow Publications
2018-01-01
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doaj-fd98f50d79f243b4a5298571e70449f32020-11-25T01:42:01ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942018-01-01912810.4103/japtr.JAPTR_314_17Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disordersBehzad Sharif MakhmalzadeFateme ChavoshyThe easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its vehicle with the skin layers. In this review, an overview of skin structure and feature of polymeric micelles as topical nanocarriers is provided. We also summarized the research studies dealing with the application of polymeric micelles for cutaneous delivery. In the past decades, numerous types of nanocarriers have been widely investigated as a novel delivery approach to improve skin penetration and localization of drugs in normal skin and dermatological diseases. Polymeric micelles are one of them, with their specific ability to encapsulate hydrophilic drugs. These carriers can enhance the therapeutic efficacy and minimize the systemic side effects of the drugs. Polymeric micelles could enhance the deposition of drugs in targeted sites of the skin in the normal and dermatological diseases such as psoriasis and acne. Nevertheless, still there is a need to investigate the mechanism of action of these carriers and the fate of polymeric micelles in skin.http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=1;spage=2;epage=8;aulast=MakhmalzadeCutaneous drug deliverynanocarrierspolymeric micellesskin topical drug delivery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Behzad Sharif Makhmalzade Fateme Chavoshy |
spellingShingle |
Behzad Sharif Makhmalzade Fateme Chavoshy Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders Journal of Advanced Pharmaceutical Technology & Research Cutaneous drug delivery nanocarriers polymeric micelles skin topical drug delivery |
author_facet |
Behzad Sharif Makhmalzade Fateme Chavoshy |
author_sort |
Behzad Sharif Makhmalzade |
title |
Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders |
title_short |
Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders |
title_full |
Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders |
title_fullStr |
Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders |
title_full_unstemmed |
Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders |
title_sort |
polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Advanced Pharmaceutical Technology & Research |
issn |
2231-4040 0976-2094 |
publishDate |
2018-01-01 |
description |
The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its vehicle with the skin layers. In this review, an overview of skin structure and feature of polymeric micelles as topical nanocarriers is provided. We also summarized the research studies dealing with the application of polymeric micelles for cutaneous delivery. In the past decades, numerous types of nanocarriers have been widely investigated as a novel delivery approach to improve skin penetration and localization of drugs in normal skin and dermatological diseases. Polymeric micelles are one of them, with their specific ability to encapsulate hydrophilic drugs. These carriers can enhance the therapeutic efficacy and minimize the systemic side effects of the drugs. Polymeric micelles could enhance the deposition of drugs in targeted sites of the skin in the normal and dermatological diseases such as psoriasis and acne. Nevertheless, still there is a need to investigate the mechanism of action of these carriers and the fate of polymeric micelles in skin. |
topic |
Cutaneous drug delivery nanocarriers polymeric micelles skin topical drug delivery |
url |
http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=1;spage=2;epage=8;aulast=Makhmalzade |
work_keys_str_mv |
AT behzadsharifmakhmalzade polymericmicellesascutaneousdrugdeliverysysteminnormalskinanddermatologicaldisorders AT fatemechavoshy polymericmicellesascutaneousdrugdeliverysysteminnormalskinanddermatologicaldisorders |
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1725038323650527232 |