Prognostic implication of a focal lesion of bone marrow in diffuse large В cell lymphosarcoma

• Main Authors: A U Magomedova, A M Kremenetskaya, I A Vorobyev, S K Kravchenko, I В Kaplanskaya, R S Samoilova, E G Gemdzhyan, A I Vorobyev
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2004-07-01
• Series: Терапевтический архив
• Subjects: chop; mature cell lesion of the bone marrow; survival
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/29997
• ISSN: 0040-3660; 2309-5342

Aim. To study prognostic implications of a focal mature cell lesion of the bone marrow (BM) in patients with diffuse large В cell lymphosarcoma (DBLCL). Material and methods. 54 patients with histologically confirmed DBLCL were given first-line CHOP and CHOP-like courses from 1996 to 2003. B-cell nature of the tumor was confirmed immunohistochemically, immunophenotypically and with flow fluorimetry. Results. In debute of the disease 16 patients had local involvement of the lymph organs (stage I-II by Enn-Arbor), 21 patients - generalized disease (stage III-IV) and 17 patients - involvement of nonlymphatic organs. Overall 3-year survival in first-line therapy in mature cell lesion of BM was 23%, without it - 0%. One-year event-free survival was 34 and 0%, respectively. Conclusion. The presence of a focal mature cell lesion of BM in DBLCL patients influences the prognosis. Regarding high frequency of transformation of mature cell lymphoproliferative diseases in DBLCL . focal lesion of BM is an indirect sign of a secondary nature of the disease.