FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8...
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doaj-fd9ee844abdf4c07b5be9e9864e8a3d22021-01-06T00:02:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-012245545510.3390/ijms22010455FUT8 Alpha-(1,6)-Fucosyltransferase in CancerKayla Bastian0Emma Scott1David J. Elliott2Jennifer Munkley3Institute of Biosciences, Newcastle University, Newcastle Upon Tyne NE1 3BZ, UKInstitute of Biosciences, Newcastle University, Newcastle Upon Tyne NE1 3BZ, UKInstitute of Biosciences, Newcastle University, Newcastle Upon Tyne NE1 3BZ, UKInstitute of Biosciences, Newcastle University, Newcastle Upon Tyne NE1 3BZ, UKAberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the innermost GlcNAc residue of N-glycans. FUT8 is frequently upregulated in cancer, and plays a critical role in immune evasion, antibody-dependent cellular cytotoxicity (ADCC), and the regulation of TGF-β, EGF, α3β1 integrin and E-Cadherin. Here, we summarise the role of FUT8 in various cancers (including lung, liver, colorectal, ovarian, prostate, breast, melanoma, thyroid, and pancreatic), discuss the potential mechanisms involved, and outline opportunities to exploit FUT8 as a critical factor in cancer therapeutics in the future.https://www.mdpi.com/1422-0067/22/1/455fut8cancerglycosylationfucosylation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kayla Bastian Emma Scott David J. Elliott Jennifer Munkley |
spellingShingle |
Kayla Bastian Emma Scott David J. Elliott Jennifer Munkley FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer International Journal of Molecular Sciences fut8 cancer glycosylation fucosylation |
author_facet |
Kayla Bastian Emma Scott David J. Elliott Jennifer Munkley |
author_sort |
Kayla Bastian |
title |
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer |
title_short |
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer |
title_full |
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer |
title_fullStr |
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer |
title_full_unstemmed |
FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer |
title_sort |
fut8 alpha-(1,6)-fucosyltransferase in cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-01-01 |
description |
Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in tumour progression from malignant transformation to metastasis and immune evasion. One key change in tumour glycosylation is altered core fucosylation. Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the innermost GlcNAc residue of N-glycans. FUT8 is frequently upregulated in cancer, and plays a critical role in immune evasion, antibody-dependent cellular cytotoxicity (ADCC), and the regulation of TGF-β, EGF, α3β1 integrin and E-Cadherin. Here, we summarise the role of FUT8 in various cancers (including lung, liver, colorectal, ovarian, prostate, breast, melanoma, thyroid, and pancreatic), discuss the potential mechanisms involved, and outline opportunities to exploit FUT8 as a critical factor in cancer therapeutics in the future. |
topic |
fut8 cancer glycosylation fucosylation |
url |
https://www.mdpi.com/1422-0067/22/1/455 |
work_keys_str_mv |
AT kaylabastian fut8alpha16fucosyltransferaseincancer AT emmascott fut8alpha16fucosyltransferaseincancer AT davidjelliott fut8alpha16fucosyltransferaseincancer AT jennifermunkley fut8alpha16fucosyltransferaseincancer |
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