Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine
Immediate vaccination of the most susceptible and epidemiological relevant animals is a crucial part of control measures that facilitate virus elimination in case of entry of foot-and-mouth disease (FMD). The objective of this study was to evaluate the effect of cattle vaccination 7 and 14 days prio...
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doaj-fda13faf753949bcadc154620a3fa55e2020-11-25T01:22:59ZengElsevierVaccine: X2590-13622020-08-015100063Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccineSergio Duffy0Norberto Fondevila1Sabrina Galdo Novo2María Aznar3Carlos Garro4Eliana Smitsaart5Gustavo Monti6Instituto de Patobiología, CICVyA-INTA Castelar, Hurlingham 1686, ArgentinaInstituto de Virología, CICVyA-INTA Castelar, Hurlingham 1686, ArgentinaServicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA), Talcahuano 1660, Martínez 1640, Prov. Buenos Aires, ArgentinaInstituto de Patobiología, CICVyA-INTA Castelar, Hurlingham 1686, ArgentinaInstituto de Patobiología, CICVyA-INTA Castelar, Hurlingham 1686, ArgentinaBiogénesis Bagó S.A., Ruta Panamericana km 38.5, Garin 1619, Prov. Buenos Aires, Argentina; Corresponding author.Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Independencia 641, Valdivia, ChileImmediate vaccination of the most susceptible and epidemiological relevant animals is a crucial part of control measures that facilitate virus elimination in case of entry of foot-and-mouth disease (FMD). The objective of this study was to evaluate the effect of cattle vaccination 7 and 14 days prior challenge using a vaccine commonly applied in systematic vaccination campaigns against transmission of FMD virus (FMDV). Transmission of FMDV was investigated in three groups of ten cattle each: one non-vaccinated group and two groups that were either vaccinated 7 days (−7/vaccinated group) or 14 days (−14/vaccinated group) before intranasal (IN) inoculation. Five cattle heads from each group were inoculated using the IN-route with the A/Argentina/2001 FMDV strain, while the remaining five cattle heads of each group were contact-exposed to inoculated cattle. Clinical signs were recorded; virus isolation and genome detection by RT-PCR were carried out on oesophageal–pharyngeal fluid (OPF) and blood. Neutralizing antibody titers and antibodies against non-structural proteins (NSP) of FMDV were also determined. Results suggest that the experimental design, virus challenge dose, and virus infectivity were appropriate and that the virus had been transmitted to naïve calves. Under the outlined experimental conditions, vaccination 7 and 14 days prior to challenge induced full clinical protection against virus inoculation. Moreover, −7/ or −14/vaccinated calves that had been contact-exposed to −7/ or −14/vaccinated IN-challenged calves, did not become infected. Consequently, no virus transmission occurred from vaccinated and subsequently infected calves to cohabitating vaccinated calves (R = 0). According to our results, early vaccination during an outbreak is effective as virus transmission can be significantly reduced using a vaccine commercially available, routinely applied in systematic vaccination campaigns.http://www.sciencedirect.com/science/article/pii/S2590136220300103Foot-and-mouth diseaseVaccinationCattleVirus transmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sergio Duffy Norberto Fondevila Sabrina Galdo Novo María Aznar Carlos Garro Eliana Smitsaart Gustavo Monti |
spellingShingle |
Sergio Duffy Norberto Fondevila Sabrina Galdo Novo María Aznar Carlos Garro Eliana Smitsaart Gustavo Monti Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine Vaccine: X Foot-and-mouth disease Vaccination Cattle Virus transmission |
author_facet |
Sergio Duffy Norberto Fondevila Sabrina Galdo Novo María Aznar Carlos Garro Eliana Smitsaart Gustavo Monti |
author_sort |
Sergio Duffy |
title |
Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
title_short |
Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
title_full |
Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
title_fullStr |
Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
title_full_unstemmed |
Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
title_sort |
reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine |
publisher |
Elsevier |
series |
Vaccine: X |
issn |
2590-1362 |
publishDate |
2020-08-01 |
description |
Immediate vaccination of the most susceptible and epidemiological relevant animals is a crucial part of control measures that facilitate virus elimination in case of entry of foot-and-mouth disease (FMD). The objective of this study was to evaluate the effect of cattle vaccination 7 and 14 days prior challenge using a vaccine commonly applied in systematic vaccination campaigns against transmission of FMD virus (FMDV). Transmission of FMDV was investigated in three groups of ten cattle each: one non-vaccinated group and two groups that were either vaccinated 7 days (−7/vaccinated group) or 14 days (−14/vaccinated group) before intranasal (IN) inoculation. Five cattle heads from each group were inoculated using the IN-route with the A/Argentina/2001 FMDV strain, while the remaining five cattle heads of each group were contact-exposed to inoculated cattle. Clinical signs were recorded; virus isolation and genome detection by RT-PCR were carried out on oesophageal–pharyngeal fluid (OPF) and blood. Neutralizing antibody titers and antibodies against non-structural proteins (NSP) of FMDV were also determined. Results suggest that the experimental design, virus challenge dose, and virus infectivity were appropriate and that the virus had been transmitted to naïve calves. Under the outlined experimental conditions, vaccination 7 and 14 days prior to challenge induced full clinical protection against virus inoculation. Moreover, −7/ or −14/vaccinated calves that had been contact-exposed to −7/ or −14/vaccinated IN-challenged calves, did not become infected. Consequently, no virus transmission occurred from vaccinated and subsequently infected calves to cohabitating vaccinated calves (R = 0). According to our results, early vaccination during an outbreak is effective as virus transmission can be significantly reduced using a vaccine commercially available, routinely applied in systematic vaccination campaigns. |
topic |
Foot-and-mouth disease Vaccination Cattle Virus transmission |
url |
http://www.sciencedirect.com/science/article/pii/S2590136220300103 |
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