Genetic Screen in Adult Drosophila Reveals That dCBP Depletion in Glial Cells Mitigates Huntington Disease Pathology through a Foxo-Dependent Pathway
Huntington’s disease (HD) is a progressive and fatal autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the first exon of the huntingtin gene (<i>HTT</i>). In spite of considerable efforts, there is currently no treatment to stop or delay the disease. Althou...
Main Authors: | Elodie Martin, Raheleh Heidari, Véronique Monnier, Hervé Tricoire |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/8/3884 |
Similar Items
-
Overexpressing Fragments of CREB-Binding Protein (CBP) to Block Transcriptional Dysregulation and Toxicity in Huntington's Disease
by: Hosier, Gregory
Published: (2012) -
Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington’s disease: of gene prioritization and context dependence
by: Frederic eParmentier, et al.
Published: (2013-06-01) -
Porcupine and CBP/β-catenin are the most suitable targets for the inhibition of canonical Wnt signaling in colorectal carcinoma cell lines*
by: Robert Kleszcz, et al.
Published: (2020-06-01) -
Structural and Functional Characterization of FOXO3a in Transcription and Apoptosis
by: Wang, Feng
Published: (2012) -
Structural and Functional Characterization of FOXO3a in Transcription and Apoptosis
by: Wang, Feng
Published: (2012)