The Role of Heat Shock Response in Insulin Resistance and Diabetes

The Role of Heat Shock Response in Insulin Resistance and Diabetes

The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators...

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Main Authors: Tatsuya Kondo, Hiroyuki Motoshima, Motoyuki Igata, Junji Kawashima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki
Format: Article
Language:English
Published: Korean Diabetes Association 2014-04-01
Series:Diabetes & Metabolism Journal
Subjects:
Chronic inflammation
Cytoprotection
Diabetes mellitus
Heat-shock response
Online Access:http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-100.pdf
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spelling doaj-fdbe50707f1c4b2b937822e6e58a56112020-11-24T20:53:54ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872014-04-0138210010610.4093/dmj.2014.38.2.10014608The Role of Heat Shock Response in Insulin Resistance and DiabetesTatsuya KondoHiroyuki MotoshimaMotoyuki IgataJunji KawashimaTakeshi MatsumuraHirofumi KaiEiichi ArakiThe expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, β-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-100.pdfChronic inflammationCytoprotectionDiabetes mellitusHeat-shock response
collection DOAJ
language English
format Article
sources DOAJ
author Tatsuya Kondo
Hiroyuki Motoshima
Motoyuki Igata
Junji Kawashima
Takeshi Matsumura
Hirofumi Kai
Eiichi Araki
spellingShingle Tatsuya Kondo
Hiroyuki Motoshima
Motoyuki Igata
Junji Kawashima
Takeshi Matsumura
Hirofumi Kai
Eiichi Araki
The Role of Heat Shock Response in Insulin Resistance and Diabetes
Diabetes & Metabolism Journal
Chronic inflammation
Cytoprotection
Diabetes mellitus
Heat-shock response
author_facet Tatsuya Kondo
Hiroyuki Motoshima
Motoyuki Igata
Junji Kawashima
Takeshi Matsumura
Hirofumi Kai
Eiichi Araki
author_sort Tatsuya Kondo
title The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_short The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_full The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_fullStr The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_full_unstemmed The Role of Heat Shock Response in Insulin Resistance and Diabetes
title_sort role of heat shock response in insulin resistance and diabetes
publisher Korean Diabetes Association
series Diabetes & Metabolism Journal
issn 2233-6079
2233-6087
publishDate 2014-04-01
description The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, β-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy.
topic Chronic inflammation
Cytoprotection
Diabetes mellitus
Heat-shock response
url http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-100.pdf
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