Targeted Therapies in Axial Psoriatic Arthritis
Specific and high-quality evidence on the efficacy of the current targeted therapies for axial disease in psoriatic arthritis (axPsA) is still scarce. Indeed, almost all the cohorts investigated in clinical trials on PsA consisted of patients with peripheral arthritis, where a small number of them a...
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2021-06-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.689984/full |
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doaj-fdc3696cd2e540e89472021032f1712d2021-06-28T05:05:28ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-06-011210.3389/fgene.2021.689984689984Targeted Therapies in Axial Psoriatic ArthritisAlberto FlorisMattia CongiaElisabetta ChessaMaria Maddalena AngioniMatteo PigaAlberto CauliSpecific and high-quality evidence on the efficacy of the current targeted therapies for axial disease in psoriatic arthritis (axPsA) is still scarce. Indeed, almost all the cohorts investigated in clinical trials on PsA consisted of patients with peripheral arthritis, where a small number of them also had axial involvement. Only one randomized controlled trial was so far specifically designed to assess the efficacy of a biological disease-modifying antirheumatic drug (DMARD) in axPsA. For other biological and synthetic targeted DMARDs, the most specific evidence for treatment in axPsA is extrapolated from post-hoc analyses based on PsA patients with concomitant peripheral and axial manifestations. Furthermore, the current trials and post-hoc analysis on axPsA are affected by major limitations, including the lack of a widely accepted definition of axPsA and the lack of specific and validated outcome measures. Finally, poor data are available on the genetics of axPsA, although alleles differentially expressed in different patterns of axPsA might offer advantages in the prospective of personalized medicine in axPsA patients. Overall, this review suggests that there is an urgent need for more reliable evidence derived from studies specifically designed for axPsA and based on a validated definition of axPsA and on specific outcome measures.https://www.frontiersin.org/articles/10.3389/fgene.2021.689984/fullpsoriatic arthritistargeted therapyspondylarthritisaxial psoriatic arthritistreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alberto Floris Mattia Congia Elisabetta Chessa Maria Maddalena Angioni Matteo Piga Alberto Cauli |
spellingShingle |
Alberto Floris Mattia Congia Elisabetta Chessa Maria Maddalena Angioni Matteo Piga Alberto Cauli Targeted Therapies in Axial Psoriatic Arthritis Frontiers in Genetics psoriatic arthritis targeted therapy spondylarthritis axial psoriatic arthritis treatment |
author_facet |
Alberto Floris Mattia Congia Elisabetta Chessa Maria Maddalena Angioni Matteo Piga Alberto Cauli |
author_sort |
Alberto Floris |
title |
Targeted Therapies in Axial Psoriatic Arthritis |
title_short |
Targeted Therapies in Axial Psoriatic Arthritis |
title_full |
Targeted Therapies in Axial Psoriatic Arthritis |
title_fullStr |
Targeted Therapies in Axial Psoriatic Arthritis |
title_full_unstemmed |
Targeted Therapies in Axial Psoriatic Arthritis |
title_sort |
targeted therapies in axial psoriatic arthritis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2021-06-01 |
description |
Specific and high-quality evidence on the efficacy of the current targeted therapies for axial disease in psoriatic arthritis (axPsA) is still scarce. Indeed, almost all the cohorts investigated in clinical trials on PsA consisted of patients with peripheral arthritis, where a small number of them also had axial involvement. Only one randomized controlled trial was so far specifically designed to assess the efficacy of a biological disease-modifying antirheumatic drug (DMARD) in axPsA. For other biological and synthetic targeted DMARDs, the most specific evidence for treatment in axPsA is extrapolated from post-hoc analyses based on PsA patients with concomitant peripheral and axial manifestations. Furthermore, the current trials and post-hoc analysis on axPsA are affected by major limitations, including the lack of a widely accepted definition of axPsA and the lack of specific and validated outcome measures. Finally, poor data are available on the genetics of axPsA, although alleles differentially expressed in different patterns of axPsA might offer advantages in the prospective of personalized medicine in axPsA patients. Overall, this review suggests that there is an urgent need for more reliable evidence derived from studies specifically designed for axPsA and based on a validated definition of axPsA and on specific outcome measures. |
topic |
psoriatic arthritis targeted therapy spondylarthritis axial psoriatic arthritis treatment |
url |
https://www.frontiersin.org/articles/10.3389/fgene.2021.689984/full |
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