IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development

IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development

Innate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sa...

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Main Authors: Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Guanling Huang, Liuliu Yang, Pingping Zhu, Ying Du, Jiayi Wu, Shu Meng, Yong Tian, Zusen Fan
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00235-x
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spelling doaj-fdcc5a6db53a4add8f579c835b2349d12021-01-31T12:26:59ZengNature Publishing GroupNature Communications2041-17232017-08-018111410.1038/s41467-017-00235-xIL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC developmentBenyu Liu0Buqing Ye1Xiaoxiao Zhu2Guanling Huang3Liuliu Yang4Pingping Zhu5Ying Du6Jiayi Wu7Shu Meng8Yong Tian9Zusen Fan10Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesInnate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sall3.https://doi.org/10.1038/s41467-017-00235-x
collection DOAJ
language English
format Article
sources DOAJ
author Benyu Liu
Buqing Ye
Xiaoxiao Zhu
Guanling Huang
Liuliu Yang
Pingping Zhu
Ying Du
Jiayi Wu
Shu Meng
Yong Tian
Zusen Fan
spellingShingle Benyu Liu
Buqing Ye
Xiaoxiao Zhu
Guanling Huang
Liuliu Yang
Pingping Zhu
Ying Du
Jiayi Wu
Shu Meng
Yong Tian
Zusen Fan
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
Nature Communications
author_facet Benyu Liu
Buqing Ye
Xiaoxiao Zhu
Guanling Huang
Liuliu Yang
Pingping Zhu
Ying Du
Jiayi Wu
Shu Meng
Yong Tian
Zusen Fan
author_sort Benyu Liu
title IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
title_short IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
title_full IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
title_fullStr IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
title_full_unstemmed IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
title_sort il-7rα glutamylation and activation of transcription factor sall3 promote group 3 ilc development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Innate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sall3.
url https://doi.org/10.1038/s41467-017-00235-x
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