IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
Innate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sa...
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2017-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00235-x |
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doaj-fdcc5a6db53a4add8f579c835b2349d12021-01-31T12:26:59ZengNature Publishing GroupNature Communications2041-17232017-08-018111410.1038/s41467-017-00235-xIL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC developmentBenyu Liu0Buqing Ye1Xiaoxiao Zhu2Guanling Huang3Liuliu Yang4Pingping Zhu5Ying Du6Jiayi Wu7Shu Meng8Yong Tian9Zusen Fan10Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of RNA Biology of CAS, Institute of Biophysics, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesInnate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sall3.https://doi.org/10.1038/s41467-017-00235-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benyu Liu Buqing Ye Xiaoxiao Zhu Guanling Huang Liuliu Yang Pingping Zhu Ying Du Jiayi Wu Shu Meng Yong Tian Zusen Fan |
spellingShingle |
Benyu Liu Buqing Ye Xiaoxiao Zhu Guanling Huang Liuliu Yang Pingping Zhu Ying Du Jiayi Wu Shu Meng Yong Tian Zusen Fan IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development Nature Communications |
author_facet |
Benyu Liu Buqing Ye Xiaoxiao Zhu Guanling Huang Liuliu Yang Pingping Zhu Ying Du Jiayi Wu Shu Meng Yong Tian Zusen Fan |
author_sort |
Benyu Liu |
title |
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development |
title_short |
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development |
title_full |
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development |
title_fullStr |
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development |
title_full_unstemmed |
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development |
title_sort |
il-7rα glutamylation and activation of transcription factor sall3 promote group 3 ilc development |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-08-01 |
description |
Innate lymphoid cells (ILC) are important regulators of mucosal immunity, but how their development and homeostasis are modulated is still unclear. Here the authors show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Rα and the induction of transcription factor Sall3. |
url |
https://doi.org/10.1038/s41467-017-00235-x |
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