Functional consequences of enhanced expression of STIM1 and Orai1 in Huh-7 hepatocellular carcinoma tumor-initiating cells

Functional consequences of enhanced expression of STIM1 and Orai1 in Huh-7 hepatocellular carcinoma tumor-initiating cells

Abstract Background The endoplasmic reticulum (ER) Ca2+ sensor, stromal interaction molecule1 (STIM1) activates the plasma membrane (PM) channel Orai1 in order to mediate store-operated Ca2+ entry (SOCE) in response to ER store depletion. Enhanced expression of STIM1 in cancer tissue has been associ...

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Bibliographic Details
Main Authors: B. Karacicek, Y. Erac, M. Tosun
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
HCC
SOCE
TIC
STIM1
Orai1
Ca2+
Online Access:http://link.springer.com/article/10.1186/s12885-019-5947-z

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