Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage
The present study aimed to explore the hepatoprotective effects of acidic hydrolysates of polysaccharide extracted from the marine clam M. veneriformis (Ah-MVPS) against ethanol- and CCl4-induced liver damage. Moreover, we also seek to probe the mechanism associated with the liver protection effect...
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doaj-fdd4f0b82dfa44198cc6599196d8d5d42020-11-25T02:01:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-04-011110.3389/fphar.2020.00446506770Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver DamageLingchong Wang0Lingchong Wang1Ying Yang2Hor-Yue Tan3Sha Li4Yibin Feng5School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing City, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong KongSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing City, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong KongSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong KongSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong KongThe present study aimed to explore the hepatoprotective effects of acidic hydrolysates of polysaccharide extracted from the marine clam M. veneriformis (Ah-MVPS) against ethanol- and CCl4-induced liver damage. Moreover, we also seek to probe the mechanism associated with the liver protection effect of Ah-MVPS. A series of animal and cell experiments were executed to detect suitable serological and histological indicators in hepatic tissues. Ah-MVPS can significantly reduce liver damage by means of an increase in hepatocyte superoxidase dismutase and inhibition of leakages of alanine aminotransferase and aspartate transaminase, as well as through alleviation of malondialdehyde excalation. Ah-MVPS inhibited steatosis and water-like hepatic deterioration in histological examination. They can suppress membrane destruction in boundaries and the collapse of reticular scaffolds of injured mouse hepatocytes and can substantially reduce the inflammatory extent of liver tissue aroused by excessive intake of ethanol or CCl4. In cell assays, Ah-MVPS markedly elevated the viability of L-02 cells exposed to an intoxication of ethanol or H2O2. The beneficial effect of Ah-MVPS might arise, at least in part, because of the amelioration of peroxidation or oxidative stress. Taken together, our findings reveal that Ah-MVPS have potential for development as protective agents to attenuate acute liver injuries.https://www.frontiersin.org/article/10.3389/fphar.2020.00446/fullMactra veneriformishydrolysatespolysaccharideacute liver damageliver-protection agent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lingchong Wang Lingchong Wang Ying Yang Hor-Yue Tan Sha Li Yibin Feng |
spellingShingle |
Lingchong Wang Lingchong Wang Ying Yang Hor-Yue Tan Sha Li Yibin Feng Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage Frontiers in Pharmacology Mactra veneriformis hydrolysates polysaccharide acute liver damage liver-protection agent |
author_facet |
Lingchong Wang Lingchong Wang Ying Yang Hor-Yue Tan Sha Li Yibin Feng |
author_sort |
Lingchong Wang |
title |
Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage |
title_short |
Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage |
title_full |
Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage |
title_fullStr |
Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage |
title_full_unstemmed |
Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage |
title_sort |
protective actions of acidic hydrolysates of polysaccharide extracted from mactra veneriformis against chemical-induced acute liver damage |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2020-04-01 |
description |
The present study aimed to explore the hepatoprotective effects of acidic hydrolysates of polysaccharide extracted from the marine clam M. veneriformis (Ah-MVPS) against ethanol- and CCl4-induced liver damage. Moreover, we also seek to probe the mechanism associated with the liver protection effect of Ah-MVPS. A series of animal and cell experiments were executed to detect suitable serological and histological indicators in hepatic tissues. Ah-MVPS can significantly reduce liver damage by means of an increase in hepatocyte superoxidase dismutase and inhibition of leakages of alanine aminotransferase and aspartate transaminase, as well as through alleviation of malondialdehyde excalation. Ah-MVPS inhibited steatosis and water-like hepatic deterioration in histological examination. They can suppress membrane destruction in boundaries and the collapse of reticular scaffolds of injured mouse hepatocytes and can substantially reduce the inflammatory extent of liver tissue aroused by excessive intake of ethanol or CCl4. In cell assays, Ah-MVPS markedly elevated the viability of L-02 cells exposed to an intoxication of ethanol or H2O2. The beneficial effect of Ah-MVPS might arise, at least in part, because of the amelioration of peroxidation or oxidative stress. Taken together, our findings reveal that Ah-MVPS have potential for development as protective agents to attenuate acute liver injuries. |
topic |
Mactra veneriformis hydrolysates polysaccharide acute liver damage liver-protection agent |
url |
https://www.frontiersin.org/article/10.3389/fphar.2020.00446/full |
work_keys_str_mv |
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