Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction

Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction

Background/Aim: Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial metabolism of dietary phosphatidylcholine has been recently associated with atherosclerosis and increased risk of cardiovascular diseases (CVD) in rodents and humans. However, the molecular mechanisms of how TMAO...

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Bibliographic Details
Main Authors:	Krishna M. Boini, Tahir Hussain, Pin-Lan Li, Sai S Koka
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Endothelial cell permeability TMAO Inflammasome Tight junction protein
Online Access:	https://www.karger.com/Article/FullText/484623

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