Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects
Breast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the id...
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doaj-fddd584491c544d0a6761b914214854a2021-09-03T18:41:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.710538710538Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and ProspectsCuicui Lu0Duncan Wei1Yahui Zhang2Peng Wang3Wen Zhang4Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Medical College of Shantou University, Shantou, ChinaDepartment of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaDepartment of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaBreast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the identification of novel ideal diagnostic and prognostic biomarkers is of utmost importance. Long non-coding RNAs (lncRNAs) are commonly defined as transcripts longer than 200 nucleotides that lack coding potential. Extensive research has shown that lncRNAs are involved in multiple human cancers, including breast cancer. LncRNAs with dysregulated expression can act as oncogenes or tumor-suppressor genes to regulate malignant transformation processes, such as proliferation, invasion, migration and drug resistance. Intriguingly, the expression profiles of lncRNAs tend to be highly cell-type-specific, tissue-specific, disease-specific or developmental stage-specific, which makes them suitable biomarkers for breast cancer diagnosis and prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2021.710538/fulllong non-coding RNAbreast cancerbiomarkerdiagnosisprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cuicui Lu Duncan Wei Yahui Zhang Peng Wang Wen Zhang |
spellingShingle |
Cuicui Lu Duncan Wei Yahui Zhang Peng Wang Wen Zhang Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects Frontiers in Oncology long non-coding RNA breast cancer biomarker diagnosis prognosis |
author_facet |
Cuicui Lu Duncan Wei Yahui Zhang Peng Wang Wen Zhang |
author_sort |
Cuicui Lu |
title |
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects |
title_short |
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects |
title_full |
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects |
title_fullStr |
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects |
title_full_unstemmed |
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects |
title_sort |
long non-coding rnas as potential diagnostic and prognostic biomarkers in breast cancer: progress and prospects |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-08-01 |
description |
Breast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the identification of novel ideal diagnostic and prognostic biomarkers is of utmost importance. Long non-coding RNAs (lncRNAs) are commonly defined as transcripts longer than 200 nucleotides that lack coding potential. Extensive research has shown that lncRNAs are involved in multiple human cancers, including breast cancer. LncRNAs with dysregulated expression can act as oncogenes or tumor-suppressor genes to regulate malignant transformation processes, such as proliferation, invasion, migration and drug resistance. Intriguingly, the expression profiles of lncRNAs tend to be highly cell-type-specific, tissue-specific, disease-specific or developmental stage-specific, which makes them suitable biomarkers for breast cancer diagnosis and prognosis. |
topic |
long non-coding RNA breast cancer biomarker diagnosis prognosis |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.710538/full |
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